Fletta eftir höfundi "Jóhannsson, Óskar Þór"

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The BRCA1 c.4096+3A>G Variant Displays Classical Characteristics of Pathogenic BRCA1 Mutations in Hereditary Breast and Ovarian Cancers, But Still Allows Homozygous Viability

Arason, Adalgeir; Agnarsson, Bjarni A.; Jóhannesdóttir, Gudrún; Jóhannsson, Óskar Þór; Hilmarsdóttir, Bylgja; Reynisdóttir, Inga; Barkardottir, Rosa Bjork (MDPI AG, 2019-11-01)

Mutations in BRCA1 result in predisposal to breast and ovarian cancers, but many variants exist with unknown clinical significance (VUS). One is BRCA1 c.4096+3A>G, which affects production of the full-length BRCA1 transcript, while augmenting transcripts ...
High expression of the vacuole membrane protein 1 (VMP1) is a potential marker of poor prognosis in HER2 positive breast cancer

Amirfallah, Arsalan; Arason, Adalgeir; Einarsson, Hjörleifur; Guðmundsdóttir, Eydís Þórunn; Freysteinsdóttir, Edda Sigríður; Ólafsdóttir, Kristrún Auður; Jóhannsson, Óskar Þór; Agnarsson, Bjarni A.; Barkardottir, Rosa Bjork; Reynisdottir, Inga (Public Library of Science (PLoS), 2019-08-23)

Background: Fusion genes result from genomic structural changes, which can lead to alterations in gene expression that supports tumor development. The aim of the study was to use fusion genes as a tool to identify new breast cancer (BC) genes with a ...

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