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Browsing by Author "Rolfsson, Óttar"

Browsing by Author "Rolfsson, Óttar"

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    Argininosuccinate lyase is a metabolic vulnerability in breast development and cancer 
    Karvelsson, Sigurður Trausti; Wang, Qiong; Hilmarsdóttir, Bylgja; Sigurðsson, Arnar; Moestue, Siver Andreas; Mælandsmo, Gunhild Mari; Halldórsson, Skarphédinn; Guðmundsson, Steinn; Rolfsson, Óttar (2021-09-17)
    Epithelial-to-mesenchymal transition (EMT) is fundamental to both normal tissue development and cancer progression. We hypothesized that EMT plasticity defines a range of metabolic phenotypes and that individual breast epithelial metabolic phenotypes ...
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    Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia 
    Arason, Ari Jon; Jóelsson, Jón Pétur; Valdimarsdóttir, Bryndís; Sigurdsson, Snaevar; Guðjónsson, Alexander; Halldorsson, Skarphedinn; Jóhannsson, Freyr; Rolfsson, Óttar; Lehmann, Fredrik; Ingthorsson, Saevar; Cherek, Paulina; Gudmundsson, Gudmundur H; Garðarsson, Friðrik R.; Page, Clive P.; Baldursson, Ólafur; Gudjonsson, Thorarinn; Kricker, Jennifer (Springer Science and Business Media LLC, 2019-06-24)
    BACKGROUND: Azithromycin (Azm) is a macrolide recognized for its disease-modifying effects and reduction in exacerbation of chronic airway diseases. It is not clear whether the beneficial effects of Azm are due to its anti-microbial activity or other ...
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    Cerebrospinal Fluid C18 Ceramide Associates with Markers of Alzheimer's Disease and Inflammation at the Pre- And Early Stages of Dementia 
    Teitsdóttir, Unnur Diljá; Halldórsson, Skarphéðinn; Rolfsson, Óttar; Lund, Sigrún H.; Jónsdóttir, María Kristín; Snædal, Jón G.; Petersen, Pétur Henry (2021-05-04)
    BACKGROUND: Understanding how dysregulation in lipid metabolism relates to the severity of Alzheimer's disease (AD) pathology might be critical in developing effective treatments. OBJECTIVE: To identify lipid species in cerebrospinal fluid (CSF) ...
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    Chemical Mutagenesis and Fluorescence-Based High-Throughput Screening for Enhanced Accumulation of Carotenoids in a Model Marine Diatom Phaeodactylum tricornutum 
    Yi, Zhiqian; Su, Yixi; Xu, Maonian; Bergmann, Andreas; Ingþórsson, Sævar; Rolfsson, Óttar; Salehi-Ashtiani, Kourosh; Brynjolfsson, Sigurdur; Fu, Weiqi (MDPI AG, 2018-08-04)
    Diatoms are a major group of unicellular algae that are rich in lipids and carotenoids. However, sustained research efforts are needed to improve the strain performance for high product yields towards commercialization. In this study, we generated a ...
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    Combined artificial high-silicate medium and LED illumination promote carotenoid accumulation in the marine diatom Phaeodactylum tricornutum 
    Yi, Zhiqian; Su, Yixi; Cherek, Paulina; Nelson, David R.; Lin, Jianping; Rolfsson, Óttar; Wu, Hua; Salehi-Ashtiani, Kourosh; Brynjolfsson, Sigurdur; Fu, Weiqi (Springer Science and Business Media LLC, 2019-12-02)
    Background: Diatoms, which can accumulate large amounts of carotenoids, are a major group of microalgae and the dominant primary producer in marine environments. Phaeodactylum tricornutum, a model diatom species, acquires little silicon for its growth ...
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    Current Status and Future Prospects of Genome-Scale Metabolic Modeling to Optimize the Use of Mesenchymal Stem Cells in Regenerative Medicine 
    Sigmarsdóttir, Þóra; McGarrity, Sarah; Rolfsson, Óttar; Yurkovich, James T.; Sigurjónsson, Ólafur E. (Frontiers Media SA, 2020-03-31)
    Mesenchymal stem cells are a promising source for externally grown tissue replacements and patient-specific immunomodulatory treatments. This promise has not yet been fulfilled in part due to production scaling issues and the need to maintain the correct ...
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    Elucidating dynamic metabolic physiology through network integration of quantitative time-course metabolomics 
    Bordbar, Aarash; Yurkovich, James T.; Paglia, Giuseppe; Rolfsson, Óttar; Sigurjónsson, Ólafur E.; Palsson, Bernhard O. (Springer Nature, 2017-04-07)
    The increasing availability of metabolomics data necessitates novel methods for deeper data analysis and interpretation. We present a flux balance analysis method that allows for the computation of dynamic intracellular metabolic changes at the cellular ...
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    Exploratory Investigation of the Plasma Proteome Associated with the Endotheliopathy of Trauma 
    Krocker, Joseph D.; Lee, Kyung Hyun; Henriksen, Hanne H.; Wang, Yao Wei Willa; Schoof, Erwin M.; Karvelsson, Sigurdur T.; Rolfsson, Óttar; Johansson, P. I.; Pedroza, Claudia; Wade, Charles E. (2022-06-01)
    Background: The endotheliopathy of trauma (EoT) is associated with increased mortality following injury. Herein, we describe the plasma proteome related to EoT in order to provide insight into the role of the endothelium within the systemic response ...
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    Metabolic Response in Endothelial Cells to Catecholamine Stimulation Associated with Increased Vascular Permeability 
    López García de Lomana, Adrián; Vilhjálmsson, Arnar Ingi; McGarrity, Sarah; Sigurðardóttir, Rósa; Anuforo, Ósk; Viktorsdóttir, Alexía Rós; Kotronoulas, Aris; Bergmann, Andreas; Franzson, Leifur; Halldórsson, Haraldur; Henriksen, Hanne H.; Wade, Charles E.; Johansson, Pär Ingemar; Rolfsson, Óttar (2022-03-15)
    Disruption to endothelial cell homeostasis results in an extensive variety of human pathologies that are particularly relevant to major trauma. Circulating catecholamines, such as adrenaline and noradrenaline, activate endothelial adrenergic receptors ...
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    Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition 
    Halldorsson, Skarphedinn; Rohatgi, Neha; Magnúsdóttir, Manuela; Choudhary, Kumari Sonal; Gudjonsson, Thorarinn; Knutsen, Erik; Barkovskaya, Anna; Hilmarsdóttir, Bylgja; Perander, Maria; Mælandsmo, Gunhild M.; Guðmundsson, Steinn; Rolfsson, Óttar (Elsevier BV, 2017-06)
    Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes place during EMT are still limited. ...
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    Metabolic systems analysis of LPS induced endothelial dysfunction applied to sepsis patient stratification 
    McGarrity, Sarah; Anuforo, Ósk; Halldórsson, Haraldur; Bergmann, Andreas; Halldórsson, Skarphéðinn; Palsson, Sirus; Henriksen, Hanne H.; Johansson, Pär Ingemar; Rolfsson, Óttar (Springer Nature, 2018-05-01)
    Endothelial dysfunction contributes to sepsis outcome. Metabolic phenotypes associated with endothelial dysfunction are not well characterised in part due to difficulties in assessing endothelial metabolism in situ. Here, we describe the construction ...
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    Visualizing metabolic network dynamics through time-series metabolomic data 
    Buchweitz, Lea F.; Yurkovich, James T.; Blessing, Christoph; Kohler, Veronika; Schwarzkopf, Fabian; King, Zachary A.; Yang, Laurence; Jóhannsson, Freyr; Sigurjónsson, Ólafur E.; Rolfsson, Óttar; Heinrich, Julian; Dräger, Andreas (Springer Science and Business Media LLC, 2020-04-03)
    Background: New technologies have given rise to an abundance of-omics data, particularly metabolomic data. The scale of these data introduces new challenges for the interpretation and extraction of knowledge, requiring the development of innovative ...