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Browsing by Author "Rolfsson, Óttar"

Browsing by Author "Rolfsson, Óttar"

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    Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia 
    Arason, Ari Jon; Jóelsson, Jón Pétur; Valdimarsdóttir, Bryndís; Sigurdsson, Snaevar; Guðjónsson, Alexander; Halldorsson, Skarphedinn; Jóhannsson, Freyr; Rolfsson, Óttar; Lehmann, Fredrik; Ingthorsson, Saevar; Cherek, Paulina; Gudmundsson, Gudmundur H; Garðarsson, Friðrik R.; Page, Clive P.; Baldursson, Ólafur; Gudjonsson, Thorarinn; Kricker, Jennifer (Springer Science and Business Media LLC, 2019-06-24)
    BACKGROUND: Azithromycin (Azm) is a macrolide recognized for its disease-modifying effects and reduction in exacerbation of chronic airway diseases. It is not clear whether the beneficial effects of Azm are due to its anti-microbial activity or other ...
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    Chemical Mutagenesis and Fluorescence-Based High-Throughput Screening for Enhanced Accumulation of Carotenoids in a Model Marine Diatom Phaeodactylum tricornutum 
    Yi, Zhiqian; Su, Yixi; Xu, Maonian; Bergmann, Andreas; Ingþórsson, Sævar; Rolfsson, Óttar; Salehi-Ashtiani, Kourosh; Brynjolfsson, Sigurdur; Fu, Weiqi (MDPI AG, 2018-08-04)
    Diatoms are a major group of unicellular algae that are rich in lipids and carotenoids. However, sustained research efforts are needed to improve the strain performance for high product yields towards commercialization. In this study, we generated a ...
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    Combined artificial high-silicate medium and LED illumination promote carotenoid accumulation in the marine diatom Phaeodactylum tricornutum 
    Yi, Zhiqian; Su, Yixi; Cherek, Paulina; Nelson, David R.; Lin, Jianping; Rolfsson, Óttar; Wu, Hua; Salehi-Ashtiani, Kourosh; Brynjolfsson, Sigurdur; Fu, Weiqi (Springer Science and Business Media LLC, 2019-12-02)
    Background: Diatoms, which can accumulate large amounts of carotenoids, are a major group of microalgae and the dominant primary producer in marine environments. Phaeodactylum tricornutum, a model diatom species, acquires little silicon for its growth ...
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    Current Status and Future Prospects of Genome-Scale Metabolic Modeling to Optimize the Use of Mesenchymal Stem Cells in Regenerative Medicine 
    Sigmarsdóttir, Þóra; McGarrity, Sarah; Rolfsson, Óttar; Yurkovich, James T.; Sigurjónsson, Ólafur E. (Frontiers Media SA, 2020-03-31)
    Mesenchymal stem cells are a promising source for externally grown tissue replacements and patient-specific immunomodulatory treatments. This promise has not yet been fulfilled in part due to production scaling issues and the need to maintain the correct ...
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    Elucidating dynamic metabolic physiology through network integration of quantitative time-course metabolomics 
    Bordbar, Aarash; Yurkovich, James T.; Paglia, Giuseppe; Rolfsson, Óttar; Sigurjónsson, Ólafur E.; Palsson, Bernhard O. (Springer Nature, 2017-04-07)
    The increasing availability of metabolomics data necessitates novel methods for deeper data analysis and interpretation. We present a flux balance analysis method that allows for the computation of dynamic intracellular metabolic changes at the cellular ...
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    Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition 
    Halldorsson, Skarphedinn; Rohatgi, Neha; Magnúsdóttir, Manuela; Choudhary, Kumari Sonal; Gudjonsson, Thorarinn; Knutsen, Erik; Barkovskaya, Anna; Hilmarsdóttir, Bylgja; Perander, Maria; Mælandsmo, Gunhild M.; Guðmundsson, Steinn; Rolfsson, Óttar (Elsevier BV, 2017-06)
    Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes place during EMT are still limited. ...
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    Metabolic systems analysis of LPS induced endothelial dysfunction applied to sepsis patient stratification 
    McGarrity, Sarah; Anuforo, Ósk; Halldórsson, Haraldur; Bergmann, Andreas; Halldórsson, Skarphéðinn; Palsson, Sirus; Henriksen, Hanne H.; Johansson, Pär Ingemar; Rolfsson, Óttar (Springer Nature, 2018-05-01)
    Endothelial dysfunction contributes to sepsis outcome. Metabolic phenotypes associated with endothelial dysfunction are not well characterised in part due to difficulties in assessing endothelial metabolism in situ. Here, we describe the construction ...
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    Visualizing metabolic network dynamics through time-series metabolomic data 
    Buchweitz, Lea F.; Yurkovich, James T.; Blessing, Christoph; Kohler, Veronika; Schwarzkopf, Fabian; King, Zachary A.; Yang, Laurence; Jóhannsson, Freyr; Sigurjónsson, Ólafur E.; Rolfsson, Óttar; Heinrich, Julian; Dräger, Andreas (Springer Science and Business Media LLC, 2020-04-03)
    Background: New technologies have given rise to an abundance of-omics data, particularly metabolomic data. The scale of these data introduces new challenges for the interpretation and extraction of knowledge, requiring the development of innovative ...