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Browsing by Author "Ogmundsdottir, Margret H"

Browsing by Author "Ogmundsdottir, Margret H"

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  • García-Llorca, Andrea; Gudmundsdottir Aspelund, Snaefridur; Ogmundsdottir, Margret H; Steingrimsson, Eirikur; Eysteinsson, Thor (Springer Science and Business Media LLC, 2019-10-28)
    Mutations in the microphthalmia-associated transcription factor (Mitf) gene can cause retinal pigment epithelium (RPE) and retinal dysfunction and degeneration. We examined retinal and RPE structure and function in 3 month old mice homo- or heterozygous ...
  • Möller, Katrin; Sigurbjornsdottir, Sara; Arnþórsson, Ásgeir O.; Pogenberg, Vivian; Dilshat, Ramile; Fock, Valerie; Brynjólfsdóttir, Sólveig Hlín; Bindesboll, Christian; Bessadóttir, Margrét; Ögmundsdóttir, Helga M.; Simonsen, Anne; Larue, Lionel; Wilmanns, Matthias; Thorsson, Vésteinn; Steingrimsson, Eirikur; Ogmundsdottir, Margret H (Springer Science and Business Media LLC, 2019-01-31)
    The MITF transcription factor is a master regulator of melanocyte development and a critical factor in melanomagenesis. The related transcription factors TFEB and TFE3 regulate lysosomal activity and autophagy processes known to be important in ...
  • Zhang, T.; Zhou, Q.; Ogmundsdottir, Margret H; Möller, Katrin; Siddaway, R.; Larue, L.; Hsing, M.; Kong, S. W.; Goding, C. R.; Palsson, Arnar; Steingrimsson, Eirikur; Pignoni, F. (The Company of Biologists, 2015-06-19)
    The v-ATPase is a fundamental eukaryotic enzyme that is central to cellular homeostasis. Although its impact on key metabolic regulators such as TORC1 is well documented, our knowledge of mechanisms that regulate v-ATPase activity is limited. Here, we ...
  • Ogmundsdottir, Margret H; Fock, Valerie; Sooman, L.; Pogenberg, V.; Dilshat, R.; Bindesbøll, C.; Ögmundsdóttir, Helga M.; Simonsen, A.; Wilmanns, M.; Steingrimsson, Eirikur (Springer Science and Business Media LLC, 2018-09-26)
    Autophagy is a degradation pathway important for cellular homeostasis. The E1-like enzyme ATG7 is a key component of the autophagy machinery, with the main function of mediating the lipidation of LC3/GABARAP during autophagosome formation. By analysing ...