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Browsing by Author "Ingvarsson, Sigurður"

Browsing by Author "Ingvarsson, Sigurður"

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  • Foxler, Daniel E.; Bridge, Katherine S.; James, Victoria; Webb, Thomas M.; Mee, Maureen; Wong, Sybil C. K.; Feng, Yunfeng; Constantin-Teodosiu, Dumitru; Petursdottir, Thorgunnur Eyfjord; Bjornsson, Johannes; Ingvarsson, Sigurður; Ratcliffe, Peter J.; Longmore, Gregory D.; Sharp, Tyson V. (Springer Nature, 2012-01-29)
    There are three prolyl hydroxylases (PHD1, 2 and 3) that regulate the hypoxia-inducible factors (HIFs), the master transcriptional regulators that respond to changes in intracellular O(2) tension. In high O(2) tension (normoxia) the PHDs hydroxylate ...
  • Liu, Dong; Liu, Cong; Wang, Xiyin; Ingvarsson, Sigurður; Chen, Huiping (Elsevier Ltd., 2014-02)
    The miR-451 was found to be frequently down-regulated in tumors, indicating that miR-451 could play an important role in carcinogenesis. This study uncovered the mechanism by which the miR-451 functions as a tumor suppressor. The target genes of miR-451 ...
  • Ingvarsson, Sigurður (Karolinska Institutet, Department of Tumor Biology, 1989-10-27)
    The aim of this study has been tq identify the structural changes during c-myc activation · in relation to tumor pathogenesis, to characterize the Bmyc gene, and to compare the structure and expression of myc gene family members. The myc family members ...
  • Liu, Dong; Liu, Cong; Wang, Xiyin; Ingvarsson, Sigurður; Chen, Huiping (Scientific Research Publishing, Inc,, 2012)
    It is known that RNA editing occurs in human cells, which can change the information transmission from DNA to RNA and proteins. Most previous studies have focused on editing of the mRNAs. Here we reported that several kinds of RNAs, including miRNA, ...