Browsing by Author "Maggadóttir, Sólrún Melkorka"

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A phase I/II escalation trial design T-RAD : Treatment of metastatic lung cancer with mRNA-engineered T cells expressing a T cell receptor targeting human telomerase reverse transcriptase (hTERT)

Maggadóttir, Sólrún Melkorka; Kvalheim, Gunnar; Wernhoff, Patrik; Sæbøe-Larssen, Stein; Revheim, Mona Elisabeth; Josefsen, Dag; Wälchli, Sébastien; Helland, Åslaug; Inderberg, Else Marit (2022-11-10)

Background: Adoptive cellular therapy (ACT) with genetically modified T cells aims to redirect T cells against resistant cancers through introduction of a T cell receptor (TCR). The Radium-4 TCR was isolated from a responding patient in a cancer ...
Targeting Telomerase with an HLA Class II-Restricted TCR for Cancer Immunotherapy

Dillard, Pierre; Köksal, Hakan; Maggadóttir, Sólrún Melkorka; Winge-Main, Anna; Pollmann, Sylvie; Menard, Mathilde; Myhre, Marit Renée; Mælandsmo, Gunhild M.; Flørenes, Vivi Ann; Gaudernack, Gustav; Kvalheim, Gunnar; Wälchli, Sébastien; Inderberg, Else Marit (2021-03-03)

T cell receptor (TCR)-engineered T cell therapy is a promising cancer treatment approach. Human telomerase reverse transcriptase (hTERT) is overexpressed in the majority of tumors and a potential target for adoptive cell therapy. We isolated a novel ...

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