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Fletta eftir höfundi "Briem, Eiríkur"

Fletta eftir höfundi "Briem, Eiríkur"

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    Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen 
    Barkovskaya, Anna; Goodwin, Craig M.; Seip, Kotryna; Hilmarsdottir, Bylgja; Pettersen, Solveig; Stalnecker, Clint; Engebraaten, Olav; Briem, Eiríkur; Der, Channing J.; Moestue, Siver A.; Gudjonsson, Thorarinn; Mælandsmo, Gunhild M.; Prasmickaite, Lina (2021-05-01)
    Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple-negative breast cancer (TNBC). Here, we used ...
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    Expression of ncRNAs on the DLK1-DIO3 Locus Is Associated With Basal and Mesenchymal Phenotype in Breast Epithelial Progenitor Cells 
    Budkova, Zuzana; Sigurðardóttir, Anna Karen; Briem, Eiríkur; Bergthorsson, Jon Thor; Sigurðsson, Snævar; Magnusson, Magnus Karl; Traustadottir, Gunnhildur Asta; Gudjonsson, Thorarinn; Hilmarsdóttir, Bylgja (Frontiers Media SA, 2020-06-16)
    Epithelial-to-mesenchymal transition (EMT) and its reversed process mesenchymal-to-epithelial transition (MET) play a critical role in epithelial plasticity during development and cancer progression. Among important regulators of these cellular processes ...
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    Functional role of microRNAs in breast morphogenesis and epithelial to mesenchymal transition 
    Briem, Eiríkur (University of Iceland, School of Health Sciences, Faculty of Medicine, 2018)
    Brjóstkirtillinn er myndaður af greinóttum kirtilgöngum sem umluktir eru æðaþelsríkum bandvef. Brjóstakrabbamein á upptök í kirtilþekjufrumum í endum kirtilganga. Brjóstakrabbameinsfrumur nýta sér ferli sem kallast bandvefsumbreyting þekjuvefjar til ...
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    Inhibition of PTP1B disrupts cell–cell adhesion and induces anoikis in breast epithelial cells 
    Hilmarsdóttir, Bylgja; Briem, Eiríkur; Halldórsson, Skarphéðinn; Kricker, Jennifer; Ingthorsson, Saevar; Gústafsdóttir, Sigrún; Mælandsmo, Gunhild M; Magnusson, Magnus Karl; Gudjonsson, Thorarinn (Springer Nature, 2017-05-11)
    Protein tyrosine phosphatase 1B (PTP1B) is a well-known inhibitor of insulin signaling pathways and inhibitors against PTP1B are being developed as promising drug candidates for treatment of obesity. PTP1B has also been linked to breast cancer both as ...
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    MiR-203a is differentially expressed during branching morphogenesis and EMT in breast progenitor cells and is a repressor of peroxidasin 
    Briem, Eiríkur; Budkova, Zuzana; Sigurðardóttir, Anna Karen; Hilmarsdóttir, Bylgja; Kricker, Jennifer; Timp, Winston; Magnusson, Magnus Karl; Traustadottir, Gunnhildur Asta; Gudjonsson, Thorarinn (Elsevier BV, 2019-02)
    MicroRNAs regulate developmental events such as branching morphogenesis, epithelial to mesenchymal transition (EMT) and its reverse process mesenchymal to epithelial transition (MET). In this study, we performed small RNA sequencing of a breast epithelial ...