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Browsing by Author "Rujescu, Dan"

Browsing by Author "Rujescu, Dan"

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    A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo 
    Skuladottir, Astros Th; Bjornsdottir, Gyda; Nawaz, Muhammad Sulaman; Petersen, Hannes; Rognvaldsson, Solvi; Moore, Kristjan Helgi Swerford; Olafsson, Pall I.; Magnusson, Sigurður H.; Bjornsdottir, Anna; Sveinsson, Olafur A.; Sigurdardottir, Gudrun R.; Sævarsdóttir, Sædís; Ivarsdottir, Erna V.; Stefánsdóttir, Lilja; Gunnarsson, Bjarni; Muhlestein, Joseph B.; Knowlton, Kirk U.; Jones, David A.; Nadauld, Lincoln D.; Hartmann, Annette M.; Rujescu, Dan; Strupp, Michael; Walters, Guðmundur Bragi; Thorgeirsson, Thorgeir E.; Jónsdóttir, Ingileif; Holm, Hilma; Thorleifsson, Gudmar; Gudbjartsson, Daniel F.; Sulem, Patrick; Stefansson, Hreinn; Stefansson, Kari (2021-10-07)
    Vertigo is the leading symptom of vestibular disorders and a major risk factor for falls. In a genome-wide association study of vertigo (Ncases = 48,072, Ncontrols = 894,541), we uncovered an association with six common sequence variants in individuals ...
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    HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry 
    Konte, Bettina; Walters, James T.R.; Rujescu, Dan; Legge, Sophie E.; Pardiñas, Antonio F.; Cohen, Dan; Pirmohamed, Munir; Tiihonen, Jari; Hartmann, Annette M.; Bogers, Jan P.; van der Weide, Jan; van der Weide, Karen; Putkonen, Anu; Repo-Tiihonen, Eila; Hallikainen, Tero; Silva, Ed; Ingimarsson, Oddur; Sigurðsson, Engilbert; Kennedy, James L.; Sullivan, Patrick F.; Rietschel, Marcella; Breen, Gerome; Stefansson, Hreinn; Stefansson, Kari; Collier, David A.; O’Donovan, Michael C.; Giegling, Ina (2021-04-12)
    The atypical antipsychotic clozapine is the only effective medication for treatment-resistant schizophrenia. However, it can also induce serious adverse drug reactions, including agranulocytosis and neutropenia. The mechanism by which it does so is ...