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Fletta eftir efnisorði "Genome-Wide Association Study"

Fletta eftir efnisorði "Genome-Wide Association Study"

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    Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma 
    Hamel, Andrew R.; Yan, Wenjun; Rouhana, John M.; Monovarfeshani, Aboozar; Jiang, Xinyi; Mehta, Puja A.; Advani, Jayshree; Luo, Yuyang; Liang, Qingnan; Rajasundaram, Skanda; Shrivastava, Arushi; Duchinski, Katherine; Mantena, Sreekar; Wang, Jiali; van Zyl, Tavé; Pasquale, Louis R.; Swaroop, Anand; Gharahkhani, Puya; Khawaja, Anthony P.; MacGregor, Stuart; Hewitt, Alex W.; Schuster, Alexander K.; Viswanathan, Ananth C.; Lotery, Andrew J.; Cree, Angela J.; Pang, Calvin P.; Brandl, Caroline; Klaver, Caroline C.W.; Hayward, Caroline; Khor, Chiea Chuen; Cheng, Ching Yu; Hammond, Christopher J.; van Duijn, Cornelia; Mackey, David A.; Stefansson, Einer; Vithana, Eranga N.; Pasutto, Francesca; Jonansson, Fridbert; Thorleifsson, Gudmar; Koh, Jacyline; Wilson, James F.; Craig, Jamie E.; Vergroesen, Joëlle E.; Fingert, John H.; Jonas, Jost B.; Stefánsson, Kári; Burdon, Kathryn P.; Chen, Li Jia; Kass, Michael; Jansonius, Nomdo M.; Pfeiffer, Norbert; Polašek, Ozren; Foster, Paul J.; Mitchell, Paul; Hysi, Pirro G.; Wojciechowski, Robert; Driessen, Sjoerd J.; Tompson, Stuart W.J.; Young, Terri L.; Wong, Tien Y.; Aung, Tin; Thorsteinsdottir, Unnur; de Vries, Victor A.; Ramdas, Wishal D.; Wang, Ya Xing; Chen, Rui; Vitart, Veronique; Sanes, Joshua R.; Wiggs, Janey L.; Segrè, Ayellet V. (2024-01-09)
    Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However, its molecular and cellular causes are not well understood. Elevated intraocular pressure (IOP) is a major ...
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    Mapping genomic loci implicates genes and synaptic biology in schizophrenia 
    Indonesia Schizophrenia Consortium; Sigurðsson, Engilbert (2022-04-08)
    Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant ...
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    Migraine, chronic kidney disease and kidney function : observational and genetic analyses 
    International Headache Genetics Consortium (2023-06-12)
    Epidemiological studies demonstrate an association between migraine and chronic kidney disease (CKD), while the genetic basis underlying the phenotypic association has not been investigated. We aimed to help avoid unnecessary interventions in individuals ...
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    Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset 
    Sævarsdóttir, Sædís; Stefansdottir, Lilja; Sulem, P.; Thorleifsson, G.; Ferkingstad, E.; Rutsdottir, G.; Glintborg, B.; Westerlind, H.; Gröndal, Gerður María; Loft, I.C.; Sorensen, S.B.; Lie, B.A.; Brink, M.; Arlestig, L.; Arnthorsson, A.O.; Baecklund, E.; Banasik, K.; Bank, S.; Bjorkman, L.I.; Ellingsen, T.; Erikstrup, C.; Frei, O.; Gjertsson, I.; Gudbjartsson, D.F.; Gudjonsson, S.A.; Halldorsson, G.H.; Hendricks, O.; Hillert, J.; Hogdall, E.; Jacobsen, Sø; Jensen, D.V.; Jonsson, Helgi; Kastbom, A.; Kockum, I.; Kristensen, S.; Kristjansdottir, Helga; Larsen, M.H.; Linauskas, A.; Hauge, E.-M.; Loft, A.G.; Lúðvíksson, Björn Rúnar; Lund, S.H.; Markusson, Þorsteinn; Masson, G.; Melsted, P.; Moore, K.H.S.; Munk, H.; Nielsen, K.R.; Norddahl, G.L.; Oddsson, A.; Olafsdottir, T.A.; Olason, P.I.; Olsson, T.; Ostrowski, S.R.; Hørslev-Petersen, K.; Rognvaldsson, S.; Sanner, H.; Silberberg, G.N.; Stefansson, H.; Sørensen, E.; Sørensen, I.J.; Turesson, C.; Bergman, T.; Alfredsson, L.; Kvien, T.K.; Brunak, Sø; Steinsson, K.; Andersen, V.; Andreassen, O.A.; Rantapää-Dahlqvist, S.; Hetland, M.L.; Klareskog, L.; Askling, J.; Padyukov, L.; Pedersen, O.B.V.; Thorsteinsdottir, U.; Jonsdottir, I.; Stefánsson, Kári (2022-04-25)
    Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) and ∼1 million ...
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    Multiomics study of nonalcoholic fatty liver disease 
    DBDS Genomic Consortium (2022-10-24)
    Nonalcoholic fatty liver (NAFL) and its sequelae are growing health problems. We performed a genome-wide association study of NAFL, cirrhosis and hepatocellular carcinoma, and integrated the findings with expression and proteomic data. For NAFL, we ...
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    Polygenic risk prediction : why and when out-of-sample prediction R2 can exceed SNP-based heritability 
    Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2023-07-06)
    In polygenic score (PGS) analysis, the coefficient of determination (R2) is a key statistic to evaluate efficacy. R2 is the proportion of phenotypic variance explained by the PGS, calculated in a cohort that is independent of the genome-wide association ...
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    PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity 
    van Setten, Jessica; Brody, Jennifer A.; Jamshidi, Yalda; Swenson, Brenton R.; Butler, Anne M.; Campbell, Harry; Del Greco, Fabiola M.; Evans, Daniel S.; Gibson, Quince; Gudbjartsson, Daniel; Kerr, Kathleen F.; Krijthe, Bouwe P.; Lyytikäinen, Leo-Pekka; Müller, Christian; Müller-Nurasyid, Martina; Nolte, Ilja M.; Padmanabhan, Sandosh; Ritchie, Marylyn D.; Robino, Antonietta; Smith, Albert Vernon; Steri, Maristella; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; Ulivi, Sheila; Verweij, Niek; Yin, Xiaoyan; Arnar, Davíð O.; Asselbergs, Folkert W.; Bader, Joel S.; Barnard, John; Bis, Josh; Blankenberg, Stefan; Boerwinkle, Eric; Bradford, Yuki; Buckley, Brendan M.; Chung, Mina K.; Crawford, Dana; den Hoed, Marcel; Denny, Josh C.; Dominiczak, Anna F.; Ehret, Georg B.; Eijgelsheim, Mark; Ellinor, Patrick T.; Felix, Stephan B.; Franco, Oscar H.; Franke, Lude; Harris, Tamara B.; Holm, Hilma; Ilaria, Gandin; Iorio, Annamaria; Kähönen, Mika; Kolcic, Ivana; Kors, Jan A.; Lakatta, Edward G.; Launer, Lenore J.; Lin, Honghuang; Lin, Henry J.; Loos, Ruth J. F.; Lubitz, Steven A.; Macfarlane, Peter W.; Magnani, Jared W.; Leach, Irene Mateo; Meitinger, Thomas; Mitchell, Braxton D.; Munzel, Thomas; Papanicolaou, George J.; Peters, Annette; Pfeufer, Arne; Pramstaller, Peter P.; Raitakari, Olli T.; Rotter, Jerome I.; Rudan, Igor; Samani, Nilesh J.; Schlessinger, David; Silva Aldana, Claudia T.; Sinner, Moritz F.; Smith, Jonathan D.; Snieder, Harold; Soliman, Elsayed Z.; Spector, Timothy D.; Stott, David J.; Strauch, Konstantin; Tarasov, Kirill V.; Þorsteinsdóttir, Unnur; Uitterlinden, Andre G.; Van Wagoner, David R.; Völker, Uwe; Völzke, Henry; Waldenberger, Melanie; Jan Westra, Harm; Wild, Philipp S.; Zeller, Tanja; Alonso, Alvaro; Avery, Christy L.; Bandinelli, Stefania; Benjamin, Emelia J.; Cucca, Francesco; Dörr, Marcus; Ferrucci, Luigi; Gasparini, Paolo; Gudnason, Vilmundur; Hayward, Caroline; Heckbert, Susan R.; Hicks, Andrew A.; Jukema, J. Wouter; Kääb, Stefan; Lehtimäki, Terho; Liu, Yongmei; Munroe, Patricia B.; Parsa, Afshin; Polasek, Ozren; Psaty, Bruce M.; Roden, Dan M.; Schnabel, Renate B.; Sinagra, Gianfranco; Stefansson, Kari; Stricker, Bruno H.; van der Harst, Pim; van Duijn, Cornelia M.; Wilson, James F.; Gharib, Sina A.; de Bakker, Paul I. W.; Isaacs, Aaron; Arking, Dan E.; Sotoodehnia, Nona (Springer Science and Business Media LLC, 2018-07-25)
    Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genome-wide association study of over 92,000 European-descent individuals ...
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    A proteogenomic signature of age-related macular degeneration in blood 
    Emilsson, Valur; Gudmundsson, Elias F; Jonmundsson, Thorarinn; Jonsson, Brynjolfur G; Twarog, Michael; Gudmundsdottir, Valborg; Li, Zhiguang; Finkel, Nancy; Poor, Stephen; Liu, Xin; Esterberg, Robert; Zhang, Yiyun; Jose, Sandra; Huang, Chia-Ling; Liao, Sha-Mei; Loureiro, Joseph; Zhang, Qin; Grosskreutz, Cynthia L; Nguyen, Andrew A; Huang, Qian; Leehy, Barrett; Pitts, Rebecca; Aspelund, Thor; Lamb, John R; Jonasson, Fridbert; Launer, Lenore J; Cotch, Mary Frances; Jennings, Lori L; Gudnason, Vilmundur; Walshe, Tony E (2022-06-13)
    Age-related macular degeneration (AMD) is one of the most common causes of visual impairment in the elderly, with a complex and still poorly understood etiology. Whole-genome association studies have discovered 34 genomic regions associated with AMD. ...
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    A proteome-wide genetic investigation identifies several sars-cov-2-exploited host targets of clinical relevance 
    Karim, Mohd A.; Shilts, Jarrod; Schwartzentruber, Jeremy; Hayhurst, James; Buniello, Annalisa; Mohammed, Elmutaz Shaikho Elhaj; Zheng, Jie; Holmes, Michael V.; Ochoa, David; Carmona, Miguel; Maranville, Joseph; Gaunt, Tom R.; Emilsson, Valur; Guðnason, Vilmundur G.; McDonagh, Ellen M.; Wright, Gavin J.; Ghoussaini, Maya; Dunham, Ian (2021-08-17)
    Background: The virus SARS-CoV-2 can exploit biological vulnerabilities (e.g. host proteins) in susceptible hosts that predispose to the development of severe COVID-19. Methods: To identify host proteins that may contribute to the risk of severe COVID-19, ...
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    Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology 
    Nielsen, K.R.; Pedersen, O.B.; Sørensen, E.; Ostrowski, S.; Johansson, P.I.; Gudbjartsson, D.; Stefansson, H.; Larsen, M.A.H.; Didriksen, M.; Sækmose, S.; Zeggini, E.; Hatzikotoulas, K.; Southam, L.; Gilly, A.; Barysenka, A.; van Meurs, J.B.J.; Boer, C.G.; Uitterlinden, A.G.; Styrkársdóttir, U.; Stefánsdóttir, L.; Esko, T.; Mägi, R.; Teder-Laving, M.; Ikegawa, S.; Terao, C.; Takuwa, H.; Meulenbelt, I.; Coutinho de Almeida, R.; Kloppenburg, M.; Tuerlings, M.; Slagboom, P.E.; Nelissen, R.R.G.H.H.; Valdes, A.M.; Mangino, M.; Tsezou, A.; Zengini, E.; Alexiadis, G.; Babis, G.C.; Cheah, K.S.E.; Wu, T.T.; Samartzis, D.; Cheung, J.P.Y.; Sham, P.C.; Kraft, P.; Kang, J.H.; Hveem, K.; Zwart, J.-A.; Luetge, A.; Skogholt, A.H.; Johnsen, M.B.; Thomas, L.F.; Winsvold, B.; Gabrielsen, M.E.; Lee, M.T.M.; Zhang, Y.; Lietman, S.A.; Shivakumar, M.; Smith, G.D.; Tobias, J.H.; Hartley, A.; Gaunt, T.R.; Zheng, J.; Wilkinson, J.M.; Steinberg, J.; Morris, A.P.; Ulfarsson, E.; Blondal, J.; Brunak, S.; Ostrowski, S.R.; Ullum, H.; Þorsteinsdóttir, U.; Stefansson, H.; Gudbjartsson, D.F.; Thorgeirsson, T.E.; Stefansson, K.; DBDS Genetic Consortium; GO Consortium (2022-02-02)
    Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report a genome-wide association study of back pain using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, 909,847 controls) and ...
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    Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura 
    Bjornsdottir, Gyda; Chalmer, Mona A.; Stefánsdóttir, Lilja; Skuladottir, Astros Th; Einarsson, Gudmundur; Andrésdóttir, Margrét; Beyter, Doruk; Ferkingstad, Egil; Gretarsdottir, Solveig; Halldórsson, Bjarni Vilhjálmur; Halldórsson, Gísli Hreinn; Helgadottir, Anna; Helgason, Hannes; Hjorleifsson Eldjarn, Grimur; Jonasdottir, Adalbjorg; Jonasdottir, Aslaug; Jónsdóttir, Ingileif; Knowlton, Kirk U.; Nadauld, Lincoln D.; Lund, Sigrún Helga; Magnusson, Olafur Th; Melsted, Páll; Moore, Kristjan H.S.; Oddsson, Asmundur; Olason, Pall I.; Sigurdsson, Asgeir; Stefansson, Olafur A.; Saemundsdottir, Jona; Sveinbjornsson, Gardar; Tragante, Vinicius; Unnsteinsdottir, Unnur; Walters, Guðmundur Bragi; Zink, Florian; Rødevand, Linn; Andreassen, Ole A.; Igland, Jannicke; Lie, Rolv T.; Haavik, Jan; Banasik, Karina; Brunak, Søren; Didriksen, Maria; T. Bruun, Mie; Erikstrup, Christian; Kogelman, Lisette J.A.; Nielsen, Kaspar R.; Sørensen, Erik; Pedersen, Ole B.; Ullum, Henrik; Bay, Jakob; Boldsen, Jens K.; Brodersen, Thorsten; Burgdorf, Kristoffer; Dinh, Khoa M.; Dowsett, Joseph; Feenstra, Bjarke; Geller, Frank; Hindhede, Lotte; Hjalgrim, Henrik; Jacobsen, Rikke L.; Jemec, Gregor; Kaspersen, Katrine; Kjerulf, Bertram D.; Larsen, Margit A.H.; Louloudis, Ioannis; Lundgaard, Agnete; Mikkelsen, Susan; Mikkelsen, Christina; Nissen, Ioanna; Nyegaard, Mette; Henriksen, Alexander P.; Rohde, Palle D.; Rostgaard, Klaus; Swinn, Michael; Thørner, Lise W.; Bruun, Mie T.; Werge, Thomas; Westergaard, David; Masson, Gisli; Þorsteinsdóttir, Unnur; Olesen, Jes; Ludvigsson, Petur; Thorarensen, Ólafur; Bjornsdottir, Anna; Sigurdardottir, Gudrun R.; Sveinsson, Ólafur Árni; Ostrowski, Sisse R.; Holm, Hilma; Gudbjartsson, Daniel F.; Thorleifsson, Gudmar; Sulem, Patrick; Stefansson, Hreinn; Thorgeirsson, Thorgeir E.; Hansen, Thomas F.; Stefánsson, Kári (2023-11)
    Migraine is a complex neurovascular disease with a range of severity and symptoms, yet mostly studied as one phenotype in genome-wide association studies (GWAS). Here we combine large GWAS datasets from six European populations to study the main migraine ...
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    Sequence variant affects GCSAML splicing, mast cell specific proteins, and risk of urticaria 
    Kristjansson, Ragnar P.; Oskarsson, Gudjon R.; Skuladottir, Astros; Oddsson, Asmundur; Rognvaldsson, Solvi; Sveinbjornsson, Gardar; Lund, Sigrun H.; Jensson, Brynjar O.; Styrmisdottir, Edda L.; Halldorsson, Gisli H.; Ferkingstad, Egil; Eldjarn, Grimur Hjorleifsson; Beyter, Doruk; Kristmundsdottir, Snædis; Juliusson, Kristinn; Fridriksdottir, Run; Arnadottir, Gudny A.; Katrinardottir, Hildigunnur; Snorradottir, Margret H.; Tragante, Vinicius; Stefansdottir, Lilja; Ivarsdottir, Erna V.; Bjornsdottir, Gyda; Halldorsson, Bjarni V.; Thorleifsson, Gudmar; Lúðvíksson, Björn Rúnar; Önundarson, Páll Torfi; Sævarsdóttir, Sædís; Melsted, Pall; Norddahl, Gudmundur L.; Björnsdóttir, Unnur Steina; Olafsdottir, Thorunn; Gudbjartsson, Daniel F.; Thorsteinsdottir, Unnur; Jonsdottir, Ingileif; Sulem, Patrick; Stefansson, Kari (2023-07-10)
    Urticaria is a skin disorder characterized by outbreaks of raised pruritic wheals. In order to identify sequence variants associated with urticaria, we performed a meta-analysis of genome-wide association studies for urticaria with a total of 40,694 ...
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    Stroke genetics informs drug discovery and risk prediction across ancestries 
    PRECISEQ Consortium; FinnGen Consortium; NINDS Stroke Genetics Network (SiGN); MEGASTROKE Consortium; SIREN Consortium; China Kadoorie Biobank Collaborative Group; VA Million Veteran Program; International Stroke Genetics Consortium (ISGC); Biobank Japan; CHARGE consortium.; GIGASTROKE Consortium; COMPASS Consortium; INVENT Consortium; Dutch Parelsnoer Initiative (PSI) Cerebrovascular Disease Study Group; Estonian Biobank (2022-09-30)
    Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had ...
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    X-chromosome and kidney function : evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements 
    Scholz, Markus; Horn, Katrin; Pott, Janne; Wuttke, Matthias; Kühnapfel, Andreas; Nasr, M. Kamal; Kirsten, Holger; Li, Yong; Hoppmann, Anselm; Gorski, Mathias; Ghasemi, Sahar; Li, Man; Tin, Adrienne; Chai, Jin Fang; Cocca, Massimiliano; Wang, Judy; Nutile, Teresa; Akiyama, Masato; Åsvold, Bjørn Olav; Bansal, Nisha; Biggs, Mary L.; Boutin, Thibaud; Brenner, Hermann; Brumpton, Ben; Burkhardt, Ralph; Cai, Jianwen; Campbell, Archie; Campbell, Harry; Chalmers, John; Chasman, Daniel I.; Chee, Miao Ling; Chee, Miao Li; Chen, Xu; Cheng, Ching Yu; Cifkova, Renata; Daviglus, Martha; Delgado, Graciela; Dittrich, Katalin; Edwards, Todd L.; Endlich, Karlhans; Michael Gaziano, J.; Giri, Ayush; Giulianini, Franco; Gordon, Scott D.; Gudbjartsson, Daniel F.; Hallan, Stein; Hamet, Pavel; Hartman, Catharina A.; Hayward, Caroline; Heid, Iris M.; Hellwege, Jacklyn N.; Holleczek, Bernd; Holm, Hilma; Hutri-Kähönen, Nina; Hveem, Kristian; Isermann, Berend; Jonas, Jost B.; Joshi, Peter K.; Kamatani, Yoichiro; Kanai, Masahiro; Kastarinen, Mika; Khor, Chiea Chuen; Kiess, Wieland; Kleber, Marcus E.; Körner, Antje; Kovacs, Peter; Krajcoviechova, Alena; Kramer, Holly; Krämer, Bernhard K.; Kuokkanen, Mikko; Kähönen, Mika; Lange, Leslie A.; Lash, James P.; Lehtimäki, Terho; Li, Hengtong; Lin, Bridget M.; Liu, Jianjun; Loeffler, Markus; Lyytikäinen, Leo Pekka; Magnusson, Patrik K.E.; Martin, Nicholas G.; Matsuda, Koichi; Milaneschi, Yuri; Mishra, Pashupati P.; Mononen, Nina; Montgomery, Grant W.; Mook-Kanamori, Dennis O.; Mychaleckyj, Josyf C.; März, Winfried; Nauck, Matthias; Nikus, Kjell; Nolte, Ilja M.; Noordam, Raymond; Okada, Yukinori; Ólafsson, Ísleifur; Oldehinkel, Albertine J.; Penninx, Brenda W.J.H.; Perola, Markus; Pirastu, Nicola; Polasek, Ozren; Porteous, David J.; Poulain, Tanja; Psaty, Bruce M.; Rabelink, Ton J.; Raffield, Laura M.; Raitakari, Olli T.; Rasheed, Humaira; Reilly, Dermot F.; Rice, Kenneth M.; Richmond, Anne; Ridker, Paul M.; Rotter, Jerome I.; Rudan, Igor; Sabanayagam, Charumathi; Salomaa, Veikko; Schneiderman, Neil; Schöttker, Ben; Sims, Mario; Snieder, Harold; Stark, Klaus J.; Stefánsson, Kári; Stocker, Hannah; Stumvoll, Michael; Sulem, Patrick; Sveinbjornsson, Gardar; Svensson, Per O.; Tai, E. Shyong; Taylor, Kent D.; Tayo, Bamidele O.; Teren, Andrej; Tham, Yih Chung; Thiery, Joachim; Thio, Chris H.L.; Thomas, Laurent F.; Tremblay, Johanne; Tönjes, Anke; van der Most, Peter J.; Vitart, Veronique; Völker, Uwe; Wang, Ya Xing; Wang, Chaolong; Wei, Wen Bin; Whitfield, John B.; Wild, Sarah H.; Wilson, James F.; Winkler, Thomas W.; Wong, Tien Yin; Woodward, Mark; Sim, Xueling; Chu, Audrey Y.; Feitosa, Mary F.; Þorsteinsdóttir, Unnur; Hung, Adriana M.; Teumer, Alexander; Franceschini, Nora; Parsa, Afshin; Köttgen, Anna; Schlosser, Pascal; Pattaro, Cristian (2024-01-18)
    X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits ...