Browsing by Subject "mRNA electroporation"

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A phase I/II escalation trial design T-RAD : Treatment of metastatic lung cancer with mRNA-engineered T cells expressing a T cell receptor targeting human telomerase reverse transcriptase (hTERT)

Maggadóttir, Sólrún Melkorka; Kvalheim, Gunnar; Wernhoff, Patrik; Sæbøe-Larssen, Stein; Revheim, Mona Elisabeth; Josefsen, Dag; Wälchli, Sébastien; Helland, Åslaug; Inderberg, Else Marit (2022-11-10)

Background: Adoptive cellular therapy (ACT) with genetically modified T cells aims to redirect T cells against resistant cancers through introduction of a T cell receptor (TCR). The Radium-4 TCR was isolated from a responding patient in a cancer ...

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