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Cerebrospinal Fluid C18 Ceramide Associates with Markers of Alzheimer's Disease and Inflammation at the Pre- And Early Stages of Dementia

Teitsdóttir, Unnur Diljá; Halldórsson, Skarphéðinn; Rolfsson, Óttar; Lund, Sigrún H.; Jónsdóttir, María Kristín; Snædal, Jón G.; Petersen, Pétur Henry (2021-05-04)

BACKGROUND: Understanding how dysregulation in lipid metabolism relates to the severity of Alzheimer's disease (AD) pathology might be critical in developing effective treatments. OBJECTIVE: To identify lipid species in cerebrospinal fluid (CSF) ...
The cerebrospinal fluid proteome of preterm infants predicts neurodevelopmental outcome

Leifsdottir, Kristin; Jost, Kerstin; Siljehav, Veronica; Thelin, Eric P.; Lassarén, Philipp; Nilsson, Peter; Haraldsson, Ásgeir; Eksborg, Staffan; Herlenius, Eric (2022-07-19)

Background: Survival rate increases for preterm infants, but long-term neurodevelopmental outcome predictors are lacking. Our primary aim was to determine whether a specific proteomic profile in cerebrospinal fluid (CSF) of preterm infants differs from ...
Phenotypic Displays of Cholinergic Enzymes Associate With Markers of Inflammation, Neurofibrillary Tangles, and Neurodegeneration in Pre- and Early Symptomatic Dementia Subjects

Teitsdottir, U.D.; Darreh-Shori, T.; Lund, S.H.; Jonsdottir, M.K.; Snaedal, J.; Petersen, P.H. (2022-05-26)

Background: Cholinergic drugs are the most commonly used drugs for the treatment of Alzheimer's disease (AD). Therefore, a better understanding of the cholinergic system and its relation to both AD-related biomarkers and cognitive functions is of high ...

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