Browsing by Subject "Retinal Vessels/pathology"

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Mouse microphthalmia-associated transcription factor (Mitf) mutations affect the structure of the retinal vasculature

Daníelsson, Stefán Broddi; García-Llorca, Andrea; Reynisson, Hallur; Eysteinsson, Thor (2022-03-29)

Purpose: Mice carrying pathogenic variants in the microphthalmia transcription factor (Mitf) gene show structural and functional changes in the retina and retinal pigment epithelium. The purpose of this study was to assess the vascular changes in Mitf ...
Nicotinamide Prevents Retinal Vascular Dropout in a Rat Model of Ocular Hypertension and Supports Ocular Blood Supply in Glaucoma Patients

Gustavsson, Simon T.; Enz, Tim J.; Tribble, James R.; Nilsson, Mattias; Lindqvist, Anna; Lindén, Christina; Hagström, Anna; Rutigliani, Carola; Lardner, Emma; Stålhammar, Gustav; Williams, Pete A.; Jóhannesson, Gauti (2023-11-01)

PURPOSE: To investigate whether nicotinamide (NAM) modulates retinal vasculature in glaucoma. METHODS: This was a prospective controlled clinical trial investigating animal and human histopathology. Participants included normotensive and ocular ...

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