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A comparative study of adjuvants effects on neonatal plasma cell survival niche in bone marrow and persistence of humoral immune responses

Pind, Auður Anna Aradóttir; Thorsdottir, Sigrun; Magnusdottir, Gudbjorg Julia; Meinke, Andreas; Del Giudice, Giuseppe; Jónsdóttir, Ingileif; Bjarnarson, Stefanía P (2022-08-03)

The neonatal immune system is distinct from the immune system of older individuals rendering neonates vulnerable to infections and poor responders to vaccination. Adjuvants can be used as tools to enhance immune responses to co-administered antigens. ...
Determining hemodilution in diagnostic bone marrow aspirated samples in plasma cell disorders by next-generation flow cytometry : Proposal for a bone marrow quality index

Óskarsson, Jón Þórir; Rögnvaldsson, Sæmundur; Thorsteinsdottir, Sigrun; Aspelund, Thor; Gunnarsson, Steinar Bragi; Hákonardóttir, Guðlaug Katrín; Sigurðardóttir, Guðrún Ásta; Þórðardóttir, Ásdís Rósa; Gíslason, Gauti Kjartan; Ólafsson, Andri; Sigurðsson, Jón Kristinn; Eyþórsson, Elías; Jónsson, Ásbjörn; Viðarsson, Brynjar; Önundarson, Páll Torfi; Agnarsson, Bjarni A.; Pálmason, Róbert; Sigurðardóttir, Margrét; Þorsteinsdóttir, Ingunn; Ólafsson, Ísleifur; Harding, Stephen; Flores-Montero, Juan; Orfao, Alberto; Durie, Brian G.M.; Love, Thorvardur Jon; Kristinsson, Sigurdur Yngvi (2023-12-01)

Hemodilution of bone marrow (BM) aspirates is a limitation of multiparameter flow cytometry (MFC) in plasma cell disorders. There is a need for a validated approach for assessing sample quality and the distribution of non-plasma cell BM populations by ...
Diabetes mellitus and risk of plasma cell and lymphoproliferative disorders in 94,579 cases and 368,348 matched controls

Shah, Urvi A.; Rögnvaldsson, Sæmundur; Derkach, Andriy; Björkholm, Magnus; Turesson, Ingemar; David, Yael; Hultcrantz, Malin; Tan, Carlyn; Hassoun, Hani; Korde, Neha; Lesokhin, Alexander; Mailankody, Sham; Kristinsson, Sigurður Yngvi; Ola Landgren, C. (2022-01-01)
Immunophenotypic assessment of clonal plasma cells and B-cells in bone marrow and blood in the diagnostic classification of early stage monoclonal gammopathies : an iSTOPMM study

Pérez-Escurza, Oihane; Flores-Montero, Juan; Óskarsson, Jón Þórir; Sanoja-Flores, Luzalba; del Pozo, Julio; Lecrevisse, Quentin; Martín, Silvia; Reed, Elín Ruth; Hákonardóttir, Guðlaug Katrín; Harding, Stephen; Þorsteinsdóttir, Sigrún; Rögnvaldsson, Sæmundur; Löve, Þorvarður Jón; Durie, Brian; Kristinsson, Sigurður Yngvi; Orfao, Alberto (2023-12-11)

Monoclonal gammopathy of undetermined significance (MGUS) is the earliest discernible stage of multiple myeloma (MM) and Waldenström’s macroglobulinemia (WM). Early diagnosis of MG may be compromised by the low-level infiltration, undetectable to ...

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