Browsing by Subject "Interleukin-6/metabolism"

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A comparative study of adjuvants effects on neonatal plasma cell survival niche in bone marrow and persistence of humoral immune responses

Pind, Auður Anna Aradóttir; Thorsdottir, Sigrun; Magnusdottir, Gudbjorg Julia; Meinke, Andreas; Del Giudice, Giuseppe; Jónsdóttir, Ingileif; Bjarnarson, Stefanía P (2022-08-03)

The neonatal immune system is distinct from the immune system of older individuals rendering neonates vulnerable to infections and poor responders to vaccination. Adjuvants can be used as tools to enhance immune responses to co-administered antigens. ...
TREM-1+ Macrophages Define a Pathogenic Cell Subset in the Intestine of Crohn's Disease Patients

Caër, Charles; Gorreja, Frida; Forsskåhl, Sophia K.; Brynjólfsson, Siggeir Fannar; Szeponik, Louis; Magnusson, Maria K.; Börjesson, Lars G.; Block, Mattias; Bexe-Lindskog, Elinor; Wick, Mary Jo (2021-02-04)

BACKGROUND AND AIMS: Uncontrolled activation of intestinal mononuclear phagocytes [MNPs] drives chronic inflammation in inflammatory bowel disease [IBD]. Triggering receptor expressed on myeloid cells 1 [TREM-1] has been implicated in the pathogenesis ...

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