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Fletta eftir höfundi "Ostacolo, Kevin"

Fletta eftir höfundi "Ostacolo, Kevin"

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    Characterization of ATG7 protein coding isoforms 
    Ostacolo, Kevin (University of Iceland, School of Health Sciences, Faculty of Medicine, 2023-11-16)
    ATG7, an essential protein for cellular homeostasis, plays a pivotal role in regulating autophagy. The autophagy process ensures the degradation and recycling of cellular components for proper cell function. ATG7 facilitates the lipidation of ATG8 ...
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    miR-9 Does Not Regulate Lamin A Expression in Metastatic Cells from Lung Adenocarcinoma 
    Guinde, Julien; Benoit, Audrey; Frankel, Diane; Robert, Stéphane; Ostacolo, Kevin; Lévy, Nicolas; Astoul, Philippe; Roll, Patrice; Kaspi, Elise (MDPI AG, 2020-02-26)
    In lung adenocarcinoma, low lamin A expression in pleural metastatic cells has been proposed as a pejorative factor. miR-9 physiologically inhibits the expression of lamin A in neural cells and seems to be a central actor in the carcinogenesis and the ...
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    PINK1 regulated mitophagy is evident in skeletal muscles 
    Singh, Francois; Wilhelm, Lea; Prescott, Alan R.; Ostacolo, Kevin; Zhao, Jin-Feng; Ogmundsdottir, Margret H.; Ganley, Ian G. (Informa, 2024-03-11)
    PINK1, mutated in familial forms of Parkinson’s disease, initiates mitophagy following mitochondrial depolarization. However, it is difficult to monitor this pathway physiologically in mice as loss of PINK1 does not alter basal mitophagy levels in most ...
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    A proximity-labeling proteomic approach to investigate invadopodia molecular landscape in breast cancer cells 
    Thuault, Sylvie; Mamelonet, Claire; Salameh, Joëlle; Ostacolo, Kevin; Chanez, Brice; Salaün, Danièle; Baudelet, Emilie; Audebert, Stéphane; Camoin, Luc; Badache, Ali (Springer Science and Business Media LLC, 2020-04-22)
    Metastatic progression is the leading cause of mortality in breast cancer. Invasive tumor cells develop invadopodia to travel through basement membranes and the interstitial matrix. Substantial efforts have been made to characterize invadopodia molecular ...