Opin vísindi

Fletta eftir höfundi "Moestue, Siver A"

Fletta eftir höfundi "Moestue, Siver A"

Röðun: Raða: Niðurstöður:

  • Icon
    Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen 
    Barkovskaya, Anna; Goodwin, Craig M.; Seip, Kotryna; Hilmarsdottir, Bylgja; Pettersen, Solveig; Stalnecker, Clint; Engebraaten, Olav; Briem, Eiríkur; Der, Channing J.; Moestue, Siver A.; Gudjonsson, Thorarinn; Mælandsmo, Gunhild M.; Prasmickaite, Lina (2021-05-01)
    Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple-negative breast cancer (TNBC). Here, we used ...
  • Icon
    Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer 
    Grinde, Maria T; Hilmarsdóttir, Bylgja; Tunset, Hanna Maja; Henriksen, Ida Marie; Kim, Jana; Haugen, Mads H; Rye, Morten Beck; Mælandsmo, Gunhild M; Moestue, Siver A (2019-05-14)
    INTRODUCTION: Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 has shown promising effects ...
  • Icon
    O-GlcNAc Transferase Inhibition Differentially Affects Breast Cancer Subtypes 
    Barkovskaya, Anna; Seip, Kotryna; Hilmarsdóttir, Bylgja; Maelandsmo, Gunhild M; Moestue, Siver A; Itkonen, Harri M (2019-04-05)
    Post-translational modification of intracellular proteins with a single N-acetylglucosamine sugar (O-GlcNAcylation) regulates signaling, proliferation, metabolism and protein stability. In breast cancer, expression of the enzyme that catalyzes ...