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Browsing by Author "Ólafsdóttir, Þórunn Ásta"

Browsing by Author "Ólafsdóttir, Þórunn Ásta"

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    Age and Influenza-Specific Pre-Vaccination Antibodies Strongly Affect Influenza Vaccine Responses in the Icelandic Population whereas Disease and Medication Have Small Effects 
    Ólafsdóttir, Þórunn Ásta; Alexandersson, Kristján F.; Sveinbjornsson, Gardar; Lapini, Giulia; Palladino, Laura; Montomoli, Emanuele; Del Giudice, Giuseppe; Gudbjartsson, Daniel; Jonsdottir, Ingileif (Frontiers Media SA, 2018-01-08)
    Influenza vaccination remains the best strategy for the prevention of influenza virus-related disease and reduction of disease severity and mortality. However, there is large individual variation in influenza vaccine responses. In this study, we ...
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    Deciphering the genetics and mechanisms of predisposition to multiple myeloma 
    Went, Molly; Duran-Lozano, Laura; Halldorsson, Gisli H.; Gunnell, Andrea; Ugidos-Damboriena, Nerea; Law, Philip; Ekdahl, Ludvig; Sud, Amit; Thorleifsson, Gudmar; Thodberg, Malte; Ólafsdóttir, Þórunn Ásta; Lamarca-Arrizabalaga, Antton; Cafaro, Caterina; Niroula, Abhishek; Ajore, Ram; Lopez de Lapuente Portilla, Aitzkoa; Ali, Zain; Pertesi, Maroulio; Goldschmidt, Hartmut; Stefansdottir, Lilja; Kristinsson, Sigurður Yngvi; Stacey, Simon N.; Löve, Þorvarður Jón; Rögnvaldsson, Sæmundur; Hajek, Roman; Vodicka, Pavel; Pettersson-Kymmer, Ulrika; Späth, Florentin; Schinke, Carolina; Van Rhee, Frits; Sulem, Patrick; Ferkingstad, Egil; Hjorleifsson Eldjarn, Grimur; Mellqvist, Ulf Henrik; Jonsdottir, Ingileif; Morgan, Gareth; Sonneveld, Pieter; Waage, Anders; Weinhold, Niels; Thomsen, Hauke; Försti, Asta; Hansson, Markus; Juul-Vangsted, Annette; Thorsteinsdottir, Unnur; Hemminki, Kari; Kaiser, Martin; Rafnar, Thorunn; Stefansson, Kari; Houlston, Richard; Nilsson, Björn (2024-08-05)
    Multiple myeloma (MM) is an incurable malignancy of plasma cells. Epidemiological studies indicate a substantial heritable component, but the underlying mechanisms remain unclear. Here, in a genome-wide association study totaling 10,906 cases and 366,221 ...
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    Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis 
    Ólafsdóttir, Þórunn Ásta; Theódórs, Fannar; Bjarnadóttir, Kristbjörg; Björnsdóttir, Unnur Steina; Agustsdottir, Arna B.; Stefánsson, Ólafur A.; Ivarsdottir, Erna; Sigurðsson, Jón K.; Benónísdóttir, Stefanía; Eyjólfsson, Guðmundur I.; Gíslason, Davíð; Gislason, Thorarinn; Guðmundsdóttir, Steinunn; Gylfason, Arnaldur; Halldórsson, Bjarni; Halldorsson, Gisli; Júlíusdóttir, Þórhildur; Kristinsdottir, Anna M.; Lúðvíksdóttir, Dóra; Ludviksson, Bjorn; Másson, Gísli; Norland, Kristjan; Onundarson, Pall; Olafsson, Isleifur; Sigurdardottir, Olof; Stefánsdóttir, Lilja; Sveinbjörnsson, Garðar; Tragante do O, Vinicius; Gudbjartsson, Daniel; Þorleifsson, Guðmar; sulem, patrick; Thorsteinsdottir, Unnur; Norddahl, Guðmundur L.; Jonsdottir, Ingileif; Stefansson, Kari (Springer Science and Business Media LLC, 2020-01-20)
    Asthma is one of the most common chronic diseases affecting both children and adults. We report a genome-wide association meta-analysis of 69,189 cases and 702,199 controls from Iceland and UK biobank. We find 88 asthma risk variants at 56 loci, 19 ...
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    Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis 
    Stacey, Simon N.; Zink, Florian; Halldórsson, Gísli Hreinn; Stefánsdóttir, Lilja; Guðjónsson, Sigurjón Axel; Einarsson, Gudmundur; Hjörleifsson, Grimur; Eiríksdóttir, Þjóðbjörg; Helgadottir, Anna; Björnsdottir, Gyda; Thorgeirsson, Thorgeir E.; Ólafsdóttir, Þórunn Ásta; Jónsdóttir, Ingileif; Gretarsdottir, Solveig; Tragante, Vinicius; Magnússon, Magnús Karl; Jonsson, Hakon; Gudmundsson, Julius; Olafsson, Sigurgeir; Holm, Hilma; Gudbjartsson, Daniel F.; Sulem, Patrick; Helgason, Agnar Sturla; Þorsteinsdóttir, Unnur; Tryggvadottir, Laufey; Rafnar, Thorunn; Melsted, Páll; Úlfarsson, Magnús Örn; Viðarsson, Brynjar; Thorleifsson, Gudmar; Stefánsson, Kári (2023-12)
    Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of 45,510 Icelandic and 130,709 UK Biobank participants combined with a mutational ...
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    Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease 
    Sævarsdóttir, Sædís; Bjarnadottir, Kristbjörg; Markusson, Thorsteinn; Berglund, Jonas; Ólafsdóttir, Þórunn Ásta; Halldórsson, Gísli Hreinn; Rutsdottir, Gudrun; Gunnarsdottir, Kristbjorg; Arnthorsson, Asgeir Orn; Lund, Sigrun H.; Stefánsdóttir, Lilja; Gudmundsson, Julius; Jóhannesson, Ari J; Sturluson, Arni; Oddsson, Asmundur; Halldorsson, Bjarni; Lúðvíksson, Björn Rúnar; Ferkingstad, Egil; Ivarsdottir, Erna V.; Sveinbjornsson, Gardar; Gröndal, Gerður María; Masson, Gisli; Eldjarn, Grimur Hjorleifsson; Thorisson, Gudmundur A.; Kristjansdottir, Katla; Knowlton, Kirk U.; Moore, Kristjan H.S.; Gudjonsson, Sigurjon A.; Rognvaldsson, Solvi; Knight, Stacey; Nadauld, Lincoln D.; Holm, Hilma; Magnusson, Olafur T.; Sulem, Patrick; Gudbjartsson, Daniel F.; Rafnar, Thorunn; Thorleifsson, Gudmar; Melsted, Páll; Norddahl, Gudmundur L.; Jónsdóttir, Ingileif; Stefánsson, Kári (2024-12)
    Autoimmune thyroid disease (AITD) is a common autoimmune disease. In a GWAS meta-analysis of 110,945 cases and 1,084,290 controls, 290 sequence variants at 225 loci are associated with AITD. Of these variants, 115 are previously unreported. Multiomics ...