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Browsing by Author "Heyman, Mats"

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Genetic Subtypes and Outcome of Patients Aged 1 to 45 Years Old With Acute Lymphoblastic Leukemia in the NOPHO ALL2008 Trial

Norén-Nyström, Ulrika; Andersen, Mette K; Barbany, Gisela; Dirse, Vaidas; Eilert-Olsen, Martine; Engvall, Marie; Harila-Saari, Arja; Heyman, Mats; Hovland, Randi; Häikiö, Satu; Jónsson, Jón Jóhannes; Karhu, Ritva; Kjeldsen, Eigil; Norberg, Anna; Preiss, Birgitte S; Pulkkinen, Kati; Quist-Paulsen, Petter; Räsänen, Hannele; Schmiegelow, Kjeld; Seitsonen, Anne; Sjögren, Helene; Tammur, Pille; Johansson, Bertil (2023-05-04)
Increase in peg-asparaginase clearance as a predictor for inactivation in patients with acute lymphoblastic leukemia

Dam, Merete; Centanni, Maddalena; Friberg, Lena E.; Centanni, Daniel; Karlsson, Mats O.; Stensig Lynggaard, Line; Johannsdottir, Inga Maria; Wik, Hilde Skuterud; Malmros, Johan; Vaitkeviciene, Goda Elizabeta; Griskevicius, Laimonas; Hallböök, Helene; Jónsson, Ólafur Gísli; Overgaard, Ulrik; Schmiegelow, Kjeld; Hansen, Stefan Nygaard; Heyman, Mats; Albertsen, Birgitte Klug (2024-04)

Asparaginase is an essential component of acute lymphoblastic leukemia (ALL) therapy, yet its associated toxicities often lead to treatment discontinuation, increasing the risk of relapse. Hypersensitivity reactions include clinical allergies, silent ...
Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia

Krali, Olga; Marincevic-Zuniga, Yanara; Arvidsson, Gustav; Enblad, Anna Pia; Lundmark, Anders; Sayyab, Shumaila; Zachariadis, Vasilios; Heinäniemi, Merja; Suhonen, Janne; Oksa, Laura; Vepsäläinen, Kaisa; Öfverholm, Ingegerd; Barbany, Gisela; Nordgren, Ann; Lilljebjörn, Henrik; Fioretos, Thoas; Madsen, Hans O.; Marquart, Hanne Vibeke; Flaegstad, Trond; Forestier, Erik; Jónsson, Ólafur Gísli; Kanerva, Jukka; Lohi, Olli; Norén-Nyström, Ulrika; Schmiegelow, Kjeld; Harila, Arja; Heyman, Mats; Lönnerholm, Gudmar; Syvänen, Ann Christine; Nordlund, Jessica (2023-12)

Genomic analyses have redefined the molecular subgrouping of pediatric acute lymphoblastic leukemia (ALL). Molecular subgroups guide risk-stratification and targeted therapies, but outcomes of recently identified subtypes are often unclear, owing to ...
Obesity as a predictor of treatment-related toxicity in children with acute lymphoblastic leukaemia.

Egnell, Christina; Heyman, Mats; Jónsson, Ólafur Gísli; Raja, Raheel A; Niinimäki, Riitta; Albertsen, Birgitte Klug; Schmiegelow, Kjeld; Stabell, Niklas; Vaitkeviciene, Goda; Lepik, Kristi; Harila-Saari, Arja; Ranta, Susanna (2022-03)

Obesity is associated with poor outcomes in childhood acute lymphoblastic leukaemia (ALL). We explored whether severe treatment-related toxicity and treatment delays could explain this observation. This study included 1 443 children aged 2·0-17·9 years ...
Thiopurine Enhanced ALL Maintenance (TEAM) : study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0–45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol

Toksvang, Linea Natalie; Als-Nielsen, Bodil; Bacon, Christopher; Bertasiute, Ruta; Duarte, Ximo; Escherich, Gabriele; Helgadóttir, Elín Anna; Johannsdottir, Inga Rinvoll; Jónsson, Ólafur Gísli; Kozlowski, Piotr; Langenskjöld, Cecilia; Lepik, Kristi; Niinimäki, Riitta; Overgaard, Ulrik Malthe; Punab, Mari; Räty, Riikka; Segers, Heidi; van der Sluis, Inge; Smith, Owen Patrick; Strullu, Marion; Vaitkevičienė, Goda; Wik, Hilde Skuterud; Heyman, Mats; Schmiegelow, Kjeld (2022-05-02)

Background: A critical challenge in current acute lymphoblastic leukemia (ALL) therapy is treatment intensification in order to reduce the relapse rate in the subset of patients at the highest risk of relapse. The year-long maintenance phase is essential ...

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