Opin vísindi

Browsing by Author "Jennings, Lori L."

Browsing by Author "Jennings, Lori L."

Sort by: Order: Results:

  • Icon
    ACE2 levels are altered in comorbidities linked to severe outcome in COVID-19 
    Emilsson, Valur; Gudmundsson, Elias F; Aspelund, Thor; Jonsson, Brynjolfur G; Gudjonsson, Alexander; Launer, Lenore J.; Lamb, John R; Gudmundsdottir, Valborg; Jennings, Lori L; Gudnason, Vilmundur (2020-06-05)
  • Icon
    Coding and regulatory variants are associated with serum protein levels and disease 
    Emilsson, Valur; Gudmundsdottir, Valborg; Gudjonsson, Alexander; Jonmundsson, Thorarinn; Jonsson, Brynjolfur G; Karim, Mohd A; Ilkov, Marjan; Staley, James R; Gudmundsson, Elias F; Launer, Lenore J; Lindeman, Jan H; Morton, Nicholas M; Aspelund, Thor; Lamb, John R; Jennings, Lori L; Gudnason, Vilmundur (2022-01-25)
    Circulating proteins can be used to diagnose and predict disease-related outcomes. A deep serum proteome survey recently revealed close associations between serum protein networks and common disease. In the current study, 54,469 low-frequency and common ...
  • Icon
    Oncostatin M reduces atherosclerosis development in APOE3Leiden.CETP mice and is associated with increased survival probability in humans 
    van Keulen, Danielle; Pouwer, Marianne G.; Emilsson, Valur; Matic, Ljubica Perisic; Pieterman, Elsbet J.; Hedin, Ulf; Gudnason, Vilmundur; Jennings, Lori L.; Holmstrøm, Kim; Nielsen, Boye Schnack; Pasterkamp, Gerard; Lindeman, Jan H.N.; van Gool, Alain J.; Sollewijn Gelpke, Maarten D.; Princen, Hans M.G.; Tempel, Dennie (2019-08-01)
    Objective Previous studies indicate a role for Oncostatin M (OSM) in atherosclerosis and other chronic inflammatory diseases for which inhibitory antibodies are in development. However, to date no intervention studies with OSM have been performed, and ...
  • Icon
    A proteogenomic signature of age-related macular degeneration in blood 
    Emilsson, Valur; Gudmundsson, Elias F; Jonmundsson, Thorarinn; Jonsson, Brynjolfur G; Twarog, Michael; Gudmundsdottir, Valborg; Li, Zhiguang; Finkel, Nancy; Poor, Stephen; Liu, Xin; Esterberg, Robert; Zhang, Yiyun; Jose, Sandra; Huang, Chia-Ling; Liao, Sha-Mei; Loureiro, Joseph; Zhang, Qin; Grosskreutz, Cynthia L; Nguyen, Andrew A; Huang, Qian; Leehy, Barrett; Pitts, Rebecca; Aspelund, Thor; Lamb, John R; Jonasson, Fridbert; Launer, Lenore J; Cotch, Mary Frances; Jennings, Lori L; Gudnason, Vilmundur; Walshe, Tony E (2022-06-13)
    Age-related macular degeneration (AMD) is one of the most common causes of visual impairment in the elderly, with a complex and still poorly understood etiology. Whole-genome association studies have discovered 34 genomic regions associated with AMD. ...
  • Icon
    Proteomic associations with forced expiratory volume : a Mendelian randomisation study 
    Axelsson, Gisli Thor; Jonmundsson, Thorarinn; Woo, Youngjae; Frick, Elisabet Alexandra; Aspelund, Thor; Loureiro, Joseph J.; Orth, Anthony P.; Jennings, Lori L.; Gudmundsson, Gunnar; Emilsson, Valur; Gudmundsdottir, Valborg; Gudnason, Vilmundur (2024-12)
    Background: A decline in forced expiratory volume (FEV1) is a hallmark of respiratory diseases that are an important cause of morbidity among the elderly. While some data exist on biomarkers that are related to FEV1, we sought to do a systematic analysis ...
  • Icon
    Serum levels of ACE2 are higher in patients with obesity and diabetes 
    Emilsson, Valur; Guðmundsson, Elías F.; Aspelund, Thor; Jónsson, Brynjólfur G.; Guðjónsson, Alexander; Launer, Lenore J.; Lamb, John R.; Guðmundsdóttir, Valborg; Jennings, Lori L.; Guðnason, Vilmundur G. (2020-12-16)
    Objective: As severity of outcome in COVID-19 is disproportionately higher among individuals with obesity, smokers, patients with hypertension, kidney disease, chronic pulmonary disease, coronary heart disease (CHD), and/or type 2 diabetes (T2D), serum ...