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Browsing by Author "Lorenzo Veiga, Blanca"

Browsing by Author "Lorenzo Veiga, Blanca"

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  • Lorenzo Veiga, Blanca (University of Iceland, School of Health Sciences, Faculty of Pharmaceutical Sciences, 2020-10-26)
    Ocular drug delivery is very challenging due to the anatomical and physiological barriers of the eye. Poor aqueous solubility of many drugs and short retention time at ocular surfaces makes the formulation of topical dosage forms even more challenging. ...
  • Lorenzo Veiga, Blanca; Sigurdsson, Hakon Hrafn; Loftsson, Thorsteinn; Alvarez-Lorenzo, Carmen (MDPI AG, 2019-05-15)
    Natamycin is the only drug approved for fungal keratitis treatment, but its low water solubility and low ocular penetration limit its efficacy. The purpose of this study was to overcome these limitations by encapsulating the drug in single or mixed ...
  • Lorenzo Veiga, Blanca; Diaz-Rodriguez, Patricia; Alvarez-Lorenzo, Carmen; Loftsson, Thorsteinn; Sigurdsson, Hakon Hrafn (MDPI AG, 2020-04-09)
    The aim of this study was to design and evaluate novel cyclodextrin (CD)-based aggregate formulations to efficiently deliver nepafenac topically to the eye structure, to treat inflammation and increase nepafenac levels in the posterior segment, thus ...
  • Lorenzo Veiga, Blanca; Sigurdsson, Hakon Hrafn; Loftsson, Thorsteinn (MDPI AG, 2019-01-11)
    The topical administration route is commonly used for targeting therapeutics to the eye; however, improving the bioavailability of drugs applied directly to the eye remains a challenge. Different strategies have been studied to address this challenge. ...