Browsing by Author "Dandekar, Abhaya M."

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The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins [version 3; peer review: 2 approved]

Chakraborty, Sandeep; Rendón-Ramírez, Adela; Ásgeirsson, Bjarni; Dutta, Mouparna; Ghosh, Anindya S.; Oda, Masataka; Venkatramani, Ravindra; Rao, Basuthkar J.; Dandekar, Abhaya M.; Goñi, Félix M. (F1000Research, 2015-01-29)

The long term side effects of any newly introduced drug is a subject of intense research, and often raging controversies. One such example is the dipeptidyl peptidase-IV (DPP4) inhibitor used for treating type 2 diabetes, which is inconclusively ...
Promiscuous scaffolds in proteins - non-native, non-additive and non-trivial

Chakraborty, Sandeep; Ásgeirsson, Bjarni; Dutta, Mouparna; Ghosh, Anindya S.; Oda, Masataka; Rendón, Adela; Goñi, Felix; Frere, Jean-Marie; Venkatramani, Ravindra; Dandekar, Abhaya M.; Rao, Basuthkar J. (F1000Research, 2014-01-20)

Promiscuity, the ability of an enzyme to catalyze diverse activities using the same active site, sets up the stage for the evolution of complex organisms through gene duplication and specialization. The detection of promiscuous motifs is crucial to ...

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