Browsing by Author "Sæbøe-Larssen, Stein"

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A phase I/II escalation trial design T-RAD : Treatment of metastatic lung cancer with mRNA-engineered T cells expressing a T cell receptor targeting human telomerase reverse transcriptase (hTERT)

Maggadóttir, Sólrún Melkorka; Kvalheim, Gunnar; Wernhoff, Patrik; Sæbøe-Larssen, Stein; Revheim, Mona Elisabeth; Josefsen, Dag; Wälchli, Sébastien; Helland, Åslaug; Inderberg, Else Marit (2022-11-10)

Background: Adoptive cellular therapy (ACT) with genetically modified T cells aims to redirect T cells against resistant cancers through introduction of a T cell receptor (TCR). The Radium-4 TCR was isolated from a responding patient in a cancer ...
Transient TCR-based T cell therapy in a patient with advanced treatment-resistant MSI-high colorectal cancer

Maggadóttir, Sólrún Melkorka; Dueland, Svein; Mensali, Nadia; Hamre, Hanne; Andresen, Per Arne; Myhre, Marit Renée; Juul, Hedvig V.; Bigalke, Iris; Lundby, Marianne; Hønnåshagen, Turid Kirsti; Sæbøe-Larssen, Stein; Josefsen, Dag; Hagtvedt, Trond; Wälchli, Sébastien; Kvalheim, Gunnar; Inderberg, Else Marit (2024-06-05)

We previously demonstrated the antitumor effectiveness of transiently T cell receptor (TCR)-redirected T cells recognizing a frameshift mutation in transforming growth factor beta receptor 2. We here describe a clinical protocol using mRNA TCR-modified ...

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