Scholz, MarkusHorn, KatrinPott, JanneWuttke, MatthiasKühnapfel, AndreasNasr, M. KamalKirsten, HolgerLi, YongHoppmann, AnselmGorski, MathiasGhasemi, SaharLi, ManTin, AdrienneChai, Jin FangCocca, MassimilianoWang, JudyNutile, TeresaAkiyama, MasatoÅsvold, Bjørn OlavBansal, NishaBiggs, Mary L.Boutin, ThibaudBrenner, HermannBrumpton, BenBurkhardt, RalphCai, JianwenCampbell, ArchieCampbell, HarryChalmers, JohnChasman, Daniel I.Chee, Miao LingChee, Miao LiChen, XuCheng, Ching YuCifkova, RenataDaviglus, MarthaDelgado, GracielaDittrich, KatalinEdwards, Todd L.Endlich, KarlhansMichael Gaziano, J.Giri, AyushGiulianini, FrancoGordon, Scott D.Gudbjartsson, Daniel F.Hallan, SteinHamet, PavelHartman, Catharina A.Hayward, CarolineHeid, Iris M.Hellwege, Jacklyn N.Holleczek, BerndHolm, HilmaHutri-Kähönen, NinaHveem, KristianIsermann, BerendJonas, Jost B.Joshi, Peter K.Kamatani, YoichiroKanai, MasahiroKastarinen, MikaKhor, Chiea ChuenKiess, WielandKleber, Marcus E.Körner, AntjeKovacs, PeterKrajcoviechova, AlenaKramer, HollyKrämer, Bernhard K.Kuokkanen, MikkoKähönen, MikaLange, Leslie A.Lash, James P.Lehtimäki, TerhoLi, HengtongLin, Bridget M.Liu, JianjunLoeffler, MarkusLyytikäinen, Leo PekkaMagnusson, Patrik K.E.Martin, Nicholas G.Matsuda, KoichiMilaneschi, YuriMishra, Pashupati P.Mononen, NinaMontgomery, Grant W.Mook-Kanamori, Dennis O.Mychaleckyj, Josyf C.März, WinfriedNauck, MatthiasNikus, KjellNolte, Ilja M.Noordam, RaymondOkada, YukinoriÓlafsson, ÍsleifurOldehinkel, Albertine J.Penninx, Brenda W.J.H.Perola, MarkusPirastu, NicolaPolasek, OzrenPorteous, David J.Poulain, TanjaPsaty, Bruce M.Rabelink, Ton J.Raffield, Laura M.Raitakari, Olli T.Rasheed, HumairaReilly, Dermot F.Rice, Kenneth M.Richmond, AnneRidker, Paul M.Rotter, Jerome I.Rudan, IgorSabanayagam, CharumathiSalomaa, VeikkoSchneiderman, NeilSchöttker, BenSims, MarioSnieder, HaroldStark, Klaus J.Stefánsson, KáriStocker, HannahStumvoll, MichaelSulem, PatrickSveinbjornsson, GardarSvensson, Per O.Tai, E. ShyongTaylor, Kent D.Tayo, Bamidele O.Teren, AndrejTham, Yih ChungThiery, JoachimThio, Chris H.L.Thomas, Laurent F.Tremblay, JohanneTönjes, Ankevan der Most, Peter J.Vitart, VeroniqueVölker, UweWang, Ya XingWang, ChaolongWei, Wen BinWhitfield, John B.Wild, Sarah H.Wilson, James F.Winkler, Thomas W.Wong, Tien YinWoodward, MarkSim, XuelingChu, Audrey Y.Feitosa, Mary F.Þorsteinsdóttir, UnnurHung, Adriana M.Teumer, AlexanderFranceschini, NoraParsa, AfshinKöttgen, AnnaSchlosser, PascalPattaro, Cristian2025-11-202025-11-202024-01-18Scholz, M, Horn, K, Pott, J, Wuttke, M, Kühnapfel, A, Nasr, M K, Kirsten, H, Li, Y, Hoppmann, A, Gorski, M, Ghasemi, S, Li, M, Tin, A, Chai, J F, Cocca, M, Wang, J, Nutile, T, Akiyama, M, Åsvold, B O, Bansal, N, Biggs, M L, Boutin, T, Brenner, H, Brumpton, B, Burkhardt, R, Cai, J, Campbell, A, Campbell, H, Chalmers, J, Chasman, D I, Chee, M L, Chee, M L, Chen, X, Cheng, C Y, Cifkova, R, Daviglus, M, Delgado, G, Dittrich, K, Edwards, T L, Endlich, K, Michael Gaziano, J, Giri, A, Giulianini, F, Gordon, S D, Gudbjartsson, D F, Hallan, S, Hamet, P, Hartman, C A, Hayward, C, Heid, I M, Hellwege, J N, Holleczek, B, Holm, H, Hutri-Kähönen, N, Hveem, K, Isermann, B, Jonas, J B, Joshi, P K, Kamatani, Y, Kanai, M, Kastarinen, M, Khor, C C, Kiess, W, Kleber, M E, Körner, A, Kovacs, P, Krajcoviechova, A, Kramer, H, Krämer, B K, Kuokkanen, M, Kähönen, M, Lange, L A, Lash, J P, Lehtimäki, T, Li, H, Lin, B M, Liu, J, Loeffler, M, Lyytikäinen, L P, Magnusson, P K E, Martin, N G, Matsuda, K, Milaneschi, Y, Mishra, P P, Mononen, N, Montgomery, G W, Mook-Kanamori, D O, Mychaleckyj, J C, März, W, Nauck, M, Nikus, K, Nolte, I M, Noordam, R, Okada, Y, Ólafsson, Í, Oldehinkel, A J, Penninx, B W J H, Perola, M, Pirastu, N, Polasek, O, Porteous, D J, Poulain, T, Psaty, B M, Rabelink, T J, Raffield, L M, Raitakari, O T, Rasheed, H, Reilly, D F, Rice, K M, Richmond, A, Ridker, P M, Rotter, J I, Rudan, I, Sabanayagam, C, Salomaa, V, Schneiderman, N, Schöttker, B, Sims, M, Snieder, H, Stark, K J, Stefánsson, K, Stocker, H, Stumvoll, M, Sulem, P, Sveinbjornsson, G, Svensson, P O, Tai, E S, Taylor, K D, Tayo, B O, Teren, A, Tham, Y C, Thiery, J, Thio, C H L, Thomas, L F, Tremblay, J, Tönjes, A, van der Most, P J, Vitart, V, Völker, U, Wang, Y X, Wang, C, Wei, W B, Whitfield, J B, Wild, S H, Wilson, J F, Winkler, T W, Wong, T Y, Woodward, M, Sim, X, Chu, A Y, Feitosa, M F, Þorsteinsdóttir, U, Hung, A M, Teumer, A, Franceschini, N, Parsa, A, Köttgen, A, Schlosser, P & Pattaro, C 2024, 'X-chromosome and kidney function : evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements', Nature Communications, vol. 15, no. 1, 586, pp. 586. https://doi.org/10.1038/s41467-024-44709-12041-1723216623577d4a3b1a4-339d-4354-8e02-b2ce77c221dc8518268456538233393unpaywall: 10.1038/s41467-024-44709-1https://hdl.handle.net/20.500.11815/7463Publisher Copyright: © 2024, The Author(s). © 2024. The Author(s).X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits (n = 908,697), identifying 23 loci genome-wide significantly associated with two of the traits: 7 for uric acid and 16 for estimated glomerular filtration rate (eGFR), including four novel eGFR loci containing the functionally plausible prioritized genes ACSL4, CLDN2, TSPAN6 and the female-specific DRP2. Further, we identified five novel sex-interactions, comprising male-specific effects at FAM9B and AR/EDA2R, and three sex-differential findings with larger genetic effect sizes in males at DCAF12L1 and MST4 and larger effect sizes in females at HPRT1. All prioritized genes in loci showing significant sex-interactions were located next to androgen response elements (ARE). Five ARE genes showed sex-differential expressions. This study contributes new insights into sex-dimorphisms of kidney traits along with new prioritized gene targets for further molecular research.4409238586eninfo:eu-repo/semantics/openAccessHumansMaleFemaleAndrogens/geneticsGenome-Wide Association StudyKidneyChromosomes, Human, X/geneticsResponse ElementsPolymorphism, Single NucleotideGenetic Predisposition to DiseaseTetraspanins/geneticsGeneral ChemistryGeneral Biochemistry,Genetics and Molecular BiologyGeneral Physics and Astronomy/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.1038/s41467-024-44709-1