Einarsdottir, Margret JonaKristjansdottir, Hallgerdur L.Bergthorsdottir, RagnhildurJohannsson, GudmundurTrimpou, PenelopeLewerin, CatharinaRagnarsson, Oskar2025-11-202025-11-202023-09-27Einarsdottir, M J, Kristjansdottir, H L, Bergthorsdottir, R, Johannsson, G, Trimpou, P, Lewerin, C & Ragnarsson, O 2023, 'Intermittent High-Dose Glucocorticoid Treatment Does Not Cause Adrenal Insufficiency in Patients with Diffuse Large B-Cell Lymphoma : A Prospective Study', Acta Haematologica, vol. 147, no. 3, pp. 360-365. https://doi.org/10.1159/0005343170001-57922341182050714a46d-234f-492b-b20c-e7bdaf6b52718517911859637757784https://hdl.handle.net/20.500.11815/7728Publisher Copyright: © 2023 The Author(s). Published by S. Karger AG, Basel.Glucocorticoid (GC) treatment suppresses the hypothalamicpituitary- adrenal axis and can cause GC-induced adrenal insufficiency. In this study, we investigated the incidence of GCinduced adrenal insufficiency in patients receiving intermittent short-term high-dose oral GC treatment for newly diagnosed diffuse large B-cell lymphoma. Cosyntropin stimulation test was used to assess adrenal function at study entry (baseline), at 2 months (before the 5th cycle), and 6 months frombaseline (3months after the last cycle). Ten patients were included (40% women). Mean age was 61 years. The mean (range) plasma morning cortisol was 407 (320 530) nmol/L at baseline, 373 (260 610) nmol/L at 2 months, and 372 (230 520) nmol/L at 6 months from baseline. All patients had normal response to cosyntropin stimulation at baseline as well as 2 and 6 months from baseline. Thus, none of the patients developed biochemically verified adrenal insufficiency. Therefore, short-term high-dose GC therapy, a commonly used adjuvant treatment in patients with malignant hematological diseases, does not seem to down-regulate the hypothalamic-pituitary-adrenal axis.6260021260021360-365eninfo:eu-repo/semantics/openAccessAdrenal insufficiencyDiffuse large B-cell lymphomaGlucocorticoidsHematology/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.1159/000534317