Háskólinn í ReykjavíkReykjavik UniversityInterrante, Mary K.Segal, HannahPeshkin, Beth N.Valdimarsdottir, HeiddisNusbaum, RachelSimiluk, MorganDeMarco, TiffaniHooker, GillianGraves, KristiIsaacs, ClaudineWood, MarieMcKinnon, WendyGarber, JudyMcCormick, ShelleyHeinzmann, JessicaKinney, Anita Y.Schwartz, Marc D.2020-02-062020-02-062017-09-01Interrante, M. K., Segal, H., Peshkin, B. N., Valdimarsdottir, H. B., Nusbaum, R., Similuk, M., DeMarco, T., Hooker, G., Graves, K., Isaacs, C., Wood, M., McKinnon, W., Garber, J., McCormick, S., Heinzmann, J., Kinney, A. Y., & Schwartz, M. D. (2017). Randomized Noninferiority Trial of Telephone vs In-Person Genetic Counseling for Hereditary Breast and Ovarian Cancer: A 12-Month Follow-Up. Jnci Cancer Spectrum, 1(1), UNSP pkx002. https://doi.org/10.1093/jncics/pkx0022515-5091 (eISSN)https://hdl.handle.net/20.500.11815/1510Background: Telephone delivery of genetic counseling is an alternative to in-person genetic counseling because it may extend the reach of genetic counseling. Previous reports have established the noninferiority of telephone counseling on short-term psychosocial and decision-making outcomes. Here we examine the long-term impact of telephone counseling (TC) vs inperson counseling (usual care [UC]). Methods: We recruited high-risk women for a noninferiority trial comparing TC with UC. Of 1057 potentially eligible women, 669 were randomly assigned to TC (n = 335) or UC (n = 334), and 512 completed the 12-month follow-up. Primary outcomes were patient-reported satisfaction with genetic testing decision, distress, and quality of life. Secondary outcomes were uptake of cancer risk management strategies. Results: TC was noninferior to UC on all primary outcomes. Satisfaction with decision (d = 0.13, lower bound of 97.5% confidence interval [CI] = -0.34) did not cross its one-point noninferiority limit, cancer-specific distress (d = -2.10, upper bound of 97.5% CI = -0.07) did not cross its four-point noninferiority limit, and genetic testing distress (d = -0.27, upper bound of 97.5% CI = 1.46), physical function (d = 0.44, lower bound of 97.5% CI = -0.91) and mental function (d = -0.04, lower bound of 97.5% CI = -1.44) did not cross their 2.5-point noninferiority limit. Bivariate analyses showed no differences in risk-reducing mastectomy or oophorectomy across groups; however, when combined, TC had significantly more risk-reducing surgeries than UC (17.8% vs 10.5%; chi(2) = 4.43, P = .04). Conclusions: Findings support telephone delivery of genetic counseling to extend the accessibility of this service without long-termadverse outcomes.eninfo:eu-repo/semantics/openAccessFemaleBreast cancerOvarian cancerGenetic counselingTelephone counselingPatient satisfactionKonurBrjóstakrabbameinEggjastokkarKrabbameinErfðaráðgjöfSjúklingafræðslaRáðgjöfSímtölSjúklingarÁnægjaSálfræðiPsychologyinfo:eu-repo/semantics/articleJNCI Cancer Spectrum10.1093/jncics/pkx002