Háskólinn í ReykjavíkReykjavik UniversityWidmer Soyka, René P.Benedikt HelgasonHazrati Marangalou, Javadvan den Bergh, Joop P.Rietbergen, Bert vanFerguson, Stephen J.2018-10-292018-10-292016-04-21Widmer Soyka RP, Helgason B, Hazrati Marangalou J, van den Bergh JP, Rietbergen Bv, Ferguson SJ (2016) The Effectiveness of Percutaneous Vertebroplasty Is Determined by the Patient-Specific Bone Condition and the Treatment Strategy. PLoS ONE 11(4): e0151680. doi:10.1371/ journal.pone.01516801932-6203https://hdl.handle.net/20.500.11815/882Vertebral fragility fractures are often treated by injecting bone cement into the collapsed vertebral bodies (vertebroplasty). The mechanisms by which vertebroplasty induces pain relief are not completely understood yet and recent debates cast doubt over the outcome of the procedure. The controversy is intensified by inconsistent results of randomized clinical trials and biomechanical studies that have investigated the effectiveness or the change in bio-mechanical response due to the reinforcement. The purpose of this study was to evaluate the effectiveness of vertebroplasty, by varying the relevant treatment parameters and (a) computationally predicting the improvement of the fracture risk depending on the chosen treatment strategy, and (b) identifying the determinants of a successful treatment.e0151680eninfo:eu-repo/semantics/openAccessFinite element methodVertebral fracturesOsteoporosis compression fracturesVertebroplastyTreatment parametersBeinþynningBeinbrotMeðferðinfo:eu-repo/semantics/articlePlos One10.1371/journal.pone.0151680