Háskóli ÍslandsUniversity of IcelandLorenzo Veiga, BlancaSigurdsson, Hakon HrafnLoftsson, Thorsteinn2020-05-282020-05-282019-01-11Lorenzo-Veiga, B.; Sigurdsson, H.H.; Loftsson, T. Nepafenac-Loaded Cyclodextrin/Polymer Nanoaggregates: A New Approach to Eye Drop Formulation. Materials 2019, 12, 229.1996-1944https://hdl.handle.net/20.500.11815/1855Publisher's version (útgefin grein)The topical administration route is commonly used for targeting therapeutics to the eye; however, improving the bioavailability of drugs applied directly to the eye remains a challenge. Different strategies have been studied to address this challenge. One of them is the use of aggregates that are formed easily by self-assembly of cyclodextrin (CD)/drug complexes in aqueous solution. The aim of this study was to design a new eye drop formulation based on aggregates formed between CD/drug complexes. For this purpose, the physicochemical properties of the aggregates associated with six CDs and selected water-soluble polymers were analysed. Complex formation was studied using differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR) and 1 H nuclear magnetic resonance spectroscopy ( 1 H-NMR). Results showed that HPβCD performed best in terms of solubilization, while γ CD performed best in terms of enhancing nanoaggregate formation. Formation of inclusion complexes was confirmed by DSC, FT-IR and 1 H-NMR studies. A mixture of 15% (w/v) γ CD and 8% (w/v) HPβCD was selected for formulation studies. It was concluded that formulations with aggregate sizes less than 1 μm and viscosity around 10-19 centipoises can be easily prepared using a mixture of CDs. Formulations containing polymeric drug/CD nanoaggregates represent an interesting strategy for enhanced topical delivery of nepafenac.229eninfo:eu-repo/semantics/openAccessAggregateComplexationCyclodextrinNepafenacOcular drug deliveryPolymerSelf-assembleLyfjaefnafræðiLyfAugnsjúkdómarLyfhrifafræðiSýklódextríninfo:eu-repo/semantics/articleMaterials10.3390/ma12020229