Volkmer, AnnaAlves, Emily ViegaBar-Zeev, HagitBarbieri, ElenaBattista, PetronillaBeales, AshleighBeber, Barbara CostaBrotherhood, EmilieCadorio, Ines RibeiroCarthery-Goulart, Maria TeresaCartwright, JadeCrutch, SebastianCroot, KarenFreitas, Maria Isabel d´ÁvilaGallée, JeanneGrasso, Stephanie M.Haley, KatarinaHendriksen, HeleenHenderson, ShalomJiskoot, LizeAlmeida, Isabel JunqueiraKindell, JackieKingma, RachelKwan-Chen, Lorinda L.Y.Lavoie, MonicaLifshitz-Ben-Basat, AdiJokel, ReginaMahut-Dubos, AuroreMatias-Guiu, Jordi A.Masson-Trottier, MichèleMeinzer, MarcusMcGowan, EllenMendez-Orellana, CarolinaMeyer, Aaron M.Millanski, CarlyMontagut, NúriaMooney, AimeeMorhardt, Darby J.Nickels, LyndseyNorvik, MonicaNowenstein, Iris EddaPaplikar, AvanthiPozzebon, MargaretRenard, AntoineRuggero, LeanneRogalski, EmilyRysop, Anna U.Sand Aronsson, FredrikSuárez-González, AidaSavage, SharonThi, Mai TranTsapkini, KyrianaTaylor-Rubin, CathleenTippett, Donna C.Unger, Ninavan Ewijk, LizetWielaert, SandraWinsnes, Ingvild ElisabethWhitworth, AnneYasa, Ibrahim CanCopland, DavidHenry, Maya L.Warren, Jason D.Varley, RosemaryWallace, Sarah J.Hardy, Chris J.D.2025-11-202025-11-202025-01Volkmer, A, Alves, E V, Bar-Zeev, H, Barbieri, E, Battista, P, Beales, A, Beber, B C, Brotherhood, E, Cadorio, I R, Carthery-Goulart, M T, Cartwright, J, Crutch, S, Croot, K, Freitas, M I DÁ, Gallée, J, Grasso, S M, Haley, K, Hendriksen, H, Henderson, S, Jiskoot, L, Almeida, I J, Kindell, J, Kingma, R, Kwan-Chen, L L Y, Lavoie, M, Lifshitz-Ben-Basat, A, Jokel, R, Mahut-Dubos, A, Matias-Guiu, J A, Masson-Trottier, M, Meinzer, M, McGowan, E, Mendez-Orellana, C, Meyer, A M, Millanski, C, Montagut, N, Mooney, A, Morhardt, D J, Nickels, L, Norvik, M, Nowenstein, I E, Paplikar, A, Pozzebon, M, Renard, A, Ruggero, L, Rogalski, E, Rysop, A U, Sand Aronsson, F, Suárez-González, A, Savage, S, Thi, M T, Tsapkini, K, Taylor-Rubin, C, Tippett, D C, Unger, N, van Ewijk, L, Wielaert, S, Winsnes, I E, Whitworth, A, Yasa, I C, Copland, D, Henry, M L, Warren, J D, Varley, R, Wallace, S J & Hardy, C J D 2025, 'An international core outcome set for primary progressive aphasia (COS-PPA) : Consensus-based recommendations for communication interventions across research and clinical settings', Alzheimer's and Dementia, vol. 21, no. 1, e14362, pp. e14362. https://doi.org/10.1002/alz.143621552-5260232858729b242fe7e-a9b7-48d5-8a64-21f141faf47a8520895831239535361https://hdl.handle.net/20.500.11815/7646Publisher Copyright: © 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.INTRODUCTION: Interventions to treat speech-language difficulties in primary progressive aphasia (PPA) often use word accuracy as a highly comparable outcome. However, there are more constructs of importance to people with PPA that have received less attention. METHODS: Following Core Outcome Set Standards for Development Recommendations (COSSTAD), this study comprised: Stage 1 – systematic review to identify measures; Stage 2 – consensus groups to identify important outcome constructs for people with PPA (n = 82) and care partners (n = 91); Stage 3 – e-Delphi consensus with 57 researchers. RESULTS: The systematic review identified 84 Outcome Measurement Instruments. Core outcome constructs identified included: (1) Participate in conversations with family and friends, (2) get words out, (3) be more fluent, (4) convey a message by any means, and (5) understand what others are saying. Researchers were unable to reach a consensus on measurement instruments. DISCUSSION: Further work is required to develop appropriate measurement instruments that address all core outcome constructs important to key stakeholders. Highlights: We introduce new symptom-led perspectives on primary progressive aphasia (PPA). The focus is on non-fluent/agrammatic (nfvPPA) and semantic (svPPA) variants. Foregrounding of early and non-verbal features of PPA and clinical trajectories is featured. We introduce a symptom-led staging scheme for PPA. We propose a prototype for a functional impairment scale, the PPA Progression Planning Aid.869866e14362eninfo:eu-repo/semantics/openAccesscore outcome setdementiainterventionsoutcome measuresprimary progressive aphasiaspeech and language therapyDelphi TechniqueAphasia, Primary Progressive/therapyHumansOutcome Assessment, Health CareConsensusCommunicationEpidemiologyHealth PolicyDevelopmental NeuroscienceNeurology (clinical)Geriatrics and GerontologyCellular and Molecular NeurosciencePsychiatry and Mental Health/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.1002/alz.14362