NOTION-2 investigators2025-11-202025-11-202025-06NOTION-2 investigators 2025, 'Transcatheter or surgical aortic valve replacement in patients with severe aortic stenosis aged 70 years or younger : A NOTION-2 substudy', American Heart Journal, vol. 284, pp. 67-70. https://doi.org/10.1016/j.ahj.2025.02.003, https://doi.org/10.1016/j.ahj.2025.02.0030002-8703237250078f1e5c536-ae79-4b67-a07b-9988fd5f90c38521926008639952377https://hdl.handle.net/20.500.11815/7815Copyright © 2025 The Author(s). Published by Elsevier Inc. All rights reserved.This NOTION-2 sub-study revealed distinct outcomes for transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) in low surgical risk patients aged ≤ 70 years with a tricuspid or bicuspid aortic valve stenosis (AS). One year after intervention, the risk of death, stroke or rehospitalization in patients with tricuspid AS was similar after TAVR when compared to SAVR (absolute risk difference: -2.0%; 95% confidence interval (CI): -11.8% to 7.7%) Conversely, in patients with bicuspid AS, TAVR was associated with a significantly higher risk of adverse outcomes (absolute risk difference: 13.8%; 95% CI: 1.2% to 26.3%). These analyses are exploratory, but highlight the importance of tailoring the intervention to the patient's clinical risk profile, life expectancy, native aortic valve morphology and the anticipated risks associated with TAVR or SAVR.477354767-70eninfo:eu-repo/semantics/openAccessAgedFemaleHumansMaleMiddle AgedAge FactorsAortic Valve/surgeryAortic Valve Stenosis/surgeryBicuspid Aortic Valve DiseaseHeart Valve Diseases/surgeryHeart Valve Prosthesis Implantation/methodsPostoperative Complications/epidemiologyRisk FactorsSeverity of Illness IndexTranscatheter Aortic Valve Replacement/methodsTreatment OutcomeCardiology and Cardiovascular Medicine/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.1016/j.ahj.2025.02.003