Háskóli ÍslandsUniversity of IcelandEyþórsson, ElíasSigurdsson, SamuelErlendsdóttir, HelgaHrafnkelsson, BirgirKristinsson, Karl G.Haraldsson, Ásgeir2020-03-302020-03-302019-01-22Eythorsson, Elias, Sigurdsson, Samuel, Erlendsdóttir, Helga, Hrafnkelsson, Birgir, Kristinsson, Karl G, & Haraldsson, Ásgeir. (2019). Increase in Tympanostomy Tube Placements despite Pneumococcal Vaccination, a Population-based Study., 30667099.0803-5253https://hdl.handle.net/20.500.11815/1671Publisher's version (útgefin grein)Aim: The aim was to estimate the impact of the 10-valent pneumococcal vaccine (PHiD-CV) on tympanostomy tube placements (TTP) in children under five years of age in Iceland. Methods: This population-based observational cohort study followed 11 consecutive birth-cohorts 2005–2015 from birth until their fifth birthday. Population registries were merged using national identification numbers. The risk of TTP was compared between birth-cohorts adjusted for the number of previous otitis media diagnoses and antimicrobial prescriptions. A Cox regression model was applied and the hazard ratio (HR) of TTP was estimated between each birth-cohort and the last vaccine non-eligible birth-cohort. The vaccine impact of PHiD-CV10 on TTP was estimated as 1-HR ×100%. Results: In total, 51 247 children were followed for 210 724 person-years, of which 14 351 underwent 20 373 procedures. The estimated vaccine impact on TTP was −6% (95% CI −16% to 2.7%). Children in the vaccine-eligible cohorts had fewer previous otitis media diagnoses and had been prescribed fewer antimicrobials prior to the procedure than children in the vaccine non-eligible cohorts. Conclusion: Despite high uptake of PHiD-CV10, tympanostomy procedures increased in Iceland during the study period. Vaccine-eligible children had milder disease prior to the procedure. The reason underlying these findings are speculative.1527-1534eninfo:eu-repo/semantics/openAccessConjugate vaccinesMiddle ear ventilationOtitis mediaPHiD-CV vaccineStreptococcus pneumoniaeBóluefniBólusetningarPneumókokkarBörnTilviksrannsóknirinfo:eu-repo/semantics/articleActa Paediatrica, International Journal of Paediatrics10.1111/apa.14724