Ingason, Arnar BragiMagnússon, Magnús KarlRagnarsson, Gunnar Bjarni2025-11-202025-11-202019-08Ingason, A B, Magnússon, M K & Ragnarsson, G B 2019, 'Ópíóíðaeitrun í kjölfar vórikónazólmeðferðar - sjúkratilfelli', Læknablaðið, vol. 105, no. 7-8, pp. 335-337. https://doi.org/10.17992/lbl.2019.0708.242, https://doi.org/10.17992/lbl.2019.0708.2421670-495935381652e6d5cdce-e801-4ae9-a48d-d9f7c2ba25aa8506989972531411569https://hdl.handle.net/20.500.11815/6239Publisher Copyright: © 2019 Laeknafelag Islands. All rights reserved.67 ára gömul kona, sem tók langverkandi ópíóíðalyf (oxýkódon) vegna langvarandi brjóstverkja, varð fyrir bráðri ópíóíðaeitrun eftir að hafin var meðferð með vórikónazóli. Vórikónazól er sveppalyf sem getur bælt virkni CYP3A4 sem er niðurbrotsensím í lifur og gegnir lykilhlutverki í umbroti ýmissa lyfja. Í þessu tilfelli jókst sermisstyrkur oxýkódons sem olli alvarlegri ópíóíðaeitrun. 67-year-old female who was taking oxycodone due to chronic chest pain suffered from opioid overdose after starting treatment with voriconazole. Voriconazole is an antifungal that inhibits CYP3A4 activity in the liver. In the case reported herein, this led to higher plasma concentration of oxycodone which caused severe opioid overdose.3764040335-337isinfo:eu-repo/semantics/openAccessAdverse effectsCytochrome P450Drug interactionsOpioidOxycodoneVoriconazoleGeneral Medicine/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.17992/lbl.2019.0708.242