Gatto, Nicole MFreund, DebbieOgata, PamelaDiaz, LisaIbarrola, AceDesai, MamtaAspelund, ThorGluckstein, Daniel2025-11-202025-11-202023-01-10Gatto, N M, Freund, D, Ogata, P, Diaz, L, Ibarrola, A, Desai, M, Aspelund, T & Gluckstein, D 2023, 'Correlates of Coronavirus Disease 2019 Inpatient Mortality at a Southern California Community Hospital With a Predominantly Hispanic/Latino Adult Population', Open Forum Infectious Diseases, vol. 10, no. 1, pp. ofad011. https://doi.org/10.1093/ofid/ofad0112328-89571557659707d7a518f-43b5-43b7-a1d5-2c83b124d56b36726553PubMedCentral: PMC9887269unpaywall: 10.1093/ofid/ofad01185158863184https://hdl.handle.net/20.500.11815/7248© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. Financial support. None.BACKGROUND: Studies of inpatient coronavirus disease 2019 (COVID-19) mortality risk factors have mainly used data from academic medical centers or large multihospital databases and have not examined populations with large proportions of Hispanic/Latino patients. In a retrospective cohort study of 4881 consecutive adult COVID-19 hospitalizations at a single community hospital in Los Angeles County with a majority Hispanic/Latino population, we evaluated factors associated with mortality. METHODS: Data on demographic characteristics, comorbidities, laboratory and clinical results, and COVID-19 therapeutics were abstracted from the electronic medical record. Cox proportional hazards regression modeled statistically significant, independently associated predictors of hospital mortality. RESULTS: Age ≥65 years (hazard ratio [HR] = 2.66; 95% confidence interval [CI] = 1.90-3.72), male sex (HR = 1.31; 95% CI = 1.07-1.60), renal disease (HR = 1.52; 95% CI = 1.18-1.95), cardiovascular disease (HR = 1.45; 95% CI = 1.18-1.78), neurological disease (HR = 1.84; 95% CI = 1.41-2.39), D-dimer ≥500 ng/mL (HR = 2.07; 95% CI = 1.43-3.0), and pulse oxygen level <88% (HR = 1.39; 95% CI = 1.13-1.71) were independently associated with increased mortality. Patient household with (1) multiple COVID-19 cases and (2) Asian, Black, or Hispanic compared with White non-Hispanic race/ethnicity were associated with reduced mortality. In hypoxic COVID-19 inpatients, remdesivir, tocilizumab, and convalescent plasma were associated with reduced mortality, and corticosteroid use was associated with increased mortality. CONCLUSIONS: We corroborate several previously identified mortality risk factors and find evidence that the combination of factors associated with mortality differ between populations.864802ofad011eninfo:eu-repo/semantics/openAccessSDG 3 - Good Health and Well-being/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.1093/ofid/ofad011