Háskóli ÍslandsUniversity of IcelandGuðmundsson, JúlíusÞorleifsson, GuðmarSigurðsson, Jón K.Stefánsdóttir, LiljaJónasson, Jón G.Guðjónsson, Sigurjón AxelGudbjartsson, DanielMásson, GísliJóhannsdóttir, HrefnaHalldórsson, Gísli H.Stacey, Simon N.Helgason, Hannessulem, patrickSenter, LeighaHe, HuilingLiyanarachchi, SandyaRingel, Matthew D.Aguillo, EsperanzaPanadero, AngelesPrats, EnriqueGarcia-Castaño, AlmudenaDe Juan, AnaRivera, FernandoXu, LiKiemeney, Lambertus A.Eyjólfsson, Guðmundur I.Sigurðardóttir, ÓlöfÓlafsson, ÍsleifurKristvinsson, HöskuldurNetea-Maier, Romana T.Jónsson, ÞorvaldurMayordomo, Jose I.Plantinga, Theo S.Hjartarson, HannesHrafnkelsson, JónSturgis, Erich M.Þorsteinsdóttir, UnnurRafnar, Thorunnde la Chapelle, AlbertStefansson, Kari2017-06-142017-06-142017-02-14Gudmundsson, J. et al. A genome-wide association study yields five novel thyroid cancer risk loci. Nat. Commun. 8, 14517 doi: 10.1038/ncomms14517 (2017).2041-1723https://hdl.handle.net/20.500.11815/304The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with Pcombined<3 × 10−8): 1q42.2 (rs12129938 in PCNXL2), 3q26.2 (rs6793295 a missense mutation in LRCC34 near TERC), 5q22.1 (rs73227498 between NREP and EPB41L4A), 10q24.33 (rs7902587 near OBFC1), and two independently associated variants at 15q22.33 (rs2289261 and rs56062135; both in SMAD3). We also confirm recently published association results from a Chinese study of a variant on 5p15.33 (rs2736100 near the TERT gene) and present a stronger association result for a moderately correlated variant (rs10069690; OR=1.20, P=3.2 × 10−7) based on our study of individuals of European ancestry. In combination, these results raise several opportunities for future studies of the pathogenesis of thyroid cancer.14517eninfo:eu-repo/semantics/openAccessCancer geneticsGenome-wide association studiesKrabbameinErfðafræðiRannsóknirinfo:eu-repo/semantics/articleNature Communications10.1038/ncomms14517