Háskóli ÍslandsUniversity of IcelandMonger, Lindsey J.Runarsdottir, Gerdur R.Suman, Sigridur G2020-08-112020-08-112020-07-16Monger, L.J., Runarsdottir, G.R. & Suman, S.G. Directed coordination study of [Pd(en)(H2O)2]2+ with hetero-tripeptides containing C-terminus methyl esters employing NMR spectroscopy. J Biol Inorg Chem 25, 811–825 (2020). https://doi.org/10.1007/s00775-020-01804-00949-82571431-1327 (eISSN)https://hdl.handle.net/20.500.11815/1976Post- print / Lokaútgáfa höfundarAlkylation of the C-terminus acids in small peptides allows direction to amine and amide coordination, while changing the peptide composition to form tetradentate κ4[n,5,5], where n = 5-, 6-, 7-, or 8-membered ring coordination geometries, can be achieved. The alkylated tripeptide ligands, TrpAlaGly(OMe), β-Asp(OtBu)AlaGly(OMe), Asp(OtBu)AlaGly(OMe), and the fully methylated GSH, γ-Glu(OMe)Cys(SMe)Gly(OMe), were synthesized and their coordination properties to [Pd(en)(H2O)2]2+ were studied. pH-dependent coordination was analyzed by NMR spectroscopy and the coordination to the alkylated tripeptides at selected pH values inferred from their NMR spectra. If selective coordination of amine/amide donors results in metal complexation, allowing for flexible and adjustable ligand frameworks, then this strategy could potentially be extended to other metal ions and peptide system.811-825eninfo:eu-repo/semantics/embargoedAccessEfnasamböndEfnasamsetninginfo:eu-repo/semantics/articleJBIC Journal of Biological Inorganic Chemistry10.1007/s00775-020-01804-0