Di, XiaxiaHarðardóttir, IngibjörgFreysdóttir, JónaWang, DongdongGustafson, Kirk RÓmarsdóttir, Sesselja SigurborgMolinski, Tadeusz F2025-11-202025-11-202023-04Di, X, Harðardóttir, I, Freysdóttir, J, Wang, D, Gustafson, K R, Ómarsdóttir, S S & Molinski, T F 2023, 'Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti', Molecules, vol. 28, no. 7, 2937. https://doi.org/10.3390/molecules280729371420-30491220528339d36d9fc-e082-4514-a9e3-617c38a7694137049700PubMedCentral: PMC1009591185152332899unpaywall: 10.3390/molecules28072937https://hdl.handle.net/20.500.11815/7166Funding Information: This research was funded by University of Iceland Research Fund (Doctoral Grant and Project Grant), grant numbers not available, AVS R&D Fund of Ministry of Fisheries and Agriculture in Iceland, grant number R 029-14, the Landspitali University Hospital Research Fund (grant number not available), and the National Institutes of Health (AI100776, AT009783, to T.F.M.). Publisher Copyright: © 2023 by the authors.Geobarrettin D (1), a new bromoindole alkaloid, was isolated from the marine sponge Geodia barretti collected from Icelandic waters. Its structure was elucidated by 1D, and 2D NMR (including 1H-15N HSQC, 1H-15N HMBC spectra), as well as HRESIMS data. Geobarrettin D (1) is a new 6-bromoindole featuring an unusual purinium herbipoline moiety. Geobarrettin D (1) decreased secretion of the pro-inflammatory cytokine IL-12p40 by human monocyte derived dendritic cells, without affecting secretion of the anti-inflammatory cytokine IL-10. Thus, compound 1 shows anti-inflammatory activity.1045055eninfo:eu-repo/semantics/openAccessAnimalsHumansGeodia/chemistryAlkaloids/pharmacologyCytokinesAnti-Inflammatory AgentsMolecular Structuredendritic cellsGeodia barrettiherbipoline6-bromoindoleanti-inflammatory activityDrug DiscoveryAnalytical ChemistryChemistry (miscellaneous)Molecular MedicinePhysical and Theoretical ChemistryPharmaceutical ScienceOrganic Chemistry/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.3390/molecules28072937