Sabaté San José, AlbaPetersen, Petur Henry2025-11-202025-11-202024Sabaté San José, A & Petersen, P H 2024, 'Absence of meningeal mast cells in the Mitf mutant mouse', Frontiers in Cellular Neuroscience, vol. 18, 1337621. https://doi.org/10.3389/fncel.2024.13376211662-5102228316408c67fe79e-3e9b-4806-85ae-a0bee8f71c1485185947550https://hdl.handle.net/20.500.11815/7594Publisher Copyright: Copyright © 2024 Sabaté San José and Petersen.Mast cells (MCs) are located in the meninges of the central nervous system (CNS), where they play key roles in the immune response. MC-deficient mice are advantageous in delineating the role of MCs in the immune response in vivo. In this study, we illustrate that a mutation in microphthalmia-associated transcription factor (Mitf) affects meningeal MC number in a dosage-dependent manner. C57BL/6J Mitf null mice lack meningeal MCs completely, whereas heterozygous mice have on average 25% fewer MCs. Mitf heterozygous mice might be a valuable tool to study the role of MCs in the meninges.5763509eninfo:eu-repo/semantics/openAccessaginginflammationmast cellsmeningesmicrophthalmia-associated transcription factorCellular and Molecular Neuroscience/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.3389/fncel.2024.1337621