Háskóli ÍslandsUniversity of IcelandUlven, Stine M.Holven, Kirsten B.Rundblad, AmandaMyhrstad, Mari C. W.Leder, LenaDahlman, IngridMello, Vanessa D. deSchwab, UrsulaCarlberg, CarstenPihlajamäki, JussiHermansen, KjeldDragsted, Lars O.Gunnarsdottir, IngibjorgCloetens, LieselotteÅkesson, BjörnRosqvist, FredrikHukkanen, JanneHerzig, Karl-HeinzSavolainen, Markku JRisérus, UlfThorsdottir , IngaPoutanen, Kaisa SArner, PeterUusitupa, MattiKolehmainen, Marjukka2020-02-102020-02-102019-12-03Ulven, S.M. et al., 2019. An Isocaloric Nordic Diet Modulates and Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome-A SYSDIET Sub-Study. Nutrients, 11(12), pp.Nutrients, 03 December 2019, Vol.11(12).2072-6643https://hdl.handle.net/20.500.11815/1516Publisher's version (útgefin grein).A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may affect immune function.2932eninfo:eu-repo/semantics/openAccessMetabolic syndromeRandomized controlled dietary interventionGene expressionPeripheral blood mononuclear cellsInflammationEfnaskiptasjúkdómarBólgurMataræðiGenarannsóknirinfo:eu-repo/semantics/articleNutrients10.3390/nu11122932