Fletta eftir efnisorði "Krabbameinsrannsóknir"

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BRCA2 related cancer, haploinsufficiency and telomere dysfunction

Þorvaldsdóttir, Birna (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-11)

Germline mutations in BRCA2 increase the risk of breast and ovarian cancer. The BRCA2 protein is involved in maintaining genomic stability through its roles in DNA double strand break repair and protection of stalled replication forks. The BRCA2 gene ...
Functional role of non-coding RNAs and extracellular matrix proteins in developmental processes and breast cancer

Budková, Zuzana (2021-04)

A better understanding of normal organ development can give deeper insight into which genes are harnessed by aberrant cells during cancer formation and progression. In my thesis, I have investigated two seemingly different, however, related, developmental ...
Mechanisms of transcriptional regulation in Waldenström’s macroglobulinemia and multiple myeloma

Anderson, Kimberley (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-04)

Transcriptional regulatory mechanisms drive the maturation of B cells to plasma cells, with a dramatic transcriptional rewiring taking place during the transition. This rewiring is dependent on a number of factors, including the transcription factor B ...

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