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Fletta eftir deild "Læknadeild (HÍ)"

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    15q11.2 CNV affects cognitive, structural and functional correlates of dyslexia and dyscalculia 
    Ulfarsson, Magnus; Walters, G B; Gústafsson, O; Steinberg, S; Silva, A; Doyle, O M; Brammer, M; Gudbjartsson, Daniel; Arnarsdóttir, S; Jonsdottir, Gudbjorg; Gísladóttir, R S; Bjornsdottir, Gyda; Helgason, H; Ellingsen, L M; Halldórsson, J G; Sæmundsen, Evald E.; Stefánsdóttir, B; Jónsson, L; Eiríksdóttir, V K; Eiríksdóttir, G R; Jóhannesdóttir, G H; Unnsteinsdóttir, U; Jónsdóttir, B; Magnúsdóttir, B B; sulem, patrick; Þorsteinsdóttir, Unnur; Sigurðsson, E; Brandeis, D; Meyer-Lindenberg, A; Stefánsson, H; Stefansson, Kari (Springer Nature, 2017-04-25)
    Several copy number variants have been associated with neuropsychiatric disorders and these variants have been shown to also influence cognitive abilities in carriers unaffected by psychiatric disorders. Previously, we associated the 15q11.2(BP1–BP2) ...
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    Advanced quantitative methods in correlating sarcopenic muscle degeneration with lower extremity function biometrics and comorbidities 
    Edmunds, Kyle; Gíslason, Magnús; Sigurðsson, Sigurður; Gudnason, Vilmundur; Harris, Tamara; Carraro, Ugo; Gargiulo, Paolo (Public Library of Science (PLoS), 2018-03-07)
    Sarcopenic muscular degeneration has been consistently identified as an independent risk factor for mortality in aging populations. Recent investigations have realized the quantitative potential of computed tomography (CT) image analysis to describe ...
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    Are symptoms of insomnia related to respiratory symptoms? Cross-sectional results from 10 European countries and Australia 
    Björnsdóttir, Erla; Lindberg, Eva; Benediktsdóttir, Bryndís; Gislason, Thorarinn; Garcia Larsen, Vanessa; Franklin, Karl; Jarvis, Debbie; Demoly, Pascal; Perret, Jennifer L; Garcia Aymerich, Judith; Arenas, Sandra Dorado; Heinrich, Joachim; Torén, Kjell; Jögi, Rain; Janson, Christer (BMJ, 2020-04-28)
    Objectives To compare the prevalence of different insomnia subtypes among middle-Aged adults from Europe and Australia and to explore the cross-sectional relationship between insomnia subtypes, respiratory symptoms and lung function. Design Cross-sectional ...
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    Assessing cardiovascular risks from a mid-thigh CT image: A tree-based machine learning approach using radiodensitometric distributions 
    Ricciardi, Carlo; Edmunds, Kyle; Recenti, Marco; Sigurdsson, Sigurdur; Gudnason, Vilmundur; Carraro, Ugo; Gargiulo, Paolo (Springer Science and Business Media LLC, 2020-02-18)
    The nonlinear trimodal regression analysis (NTRA) method based on radiodensitometric CT distributions was recently developed and assessed for the quantification of lower extremity function and nutritional parameters in aging subjects. However, the use ...
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    Association of glial and neuronal degeneration markers with Alzheimer’s disease cerebrospinal fluid profile and cognitive functions 
    Teitsdóttir, Unnur Diljá; Jónsdóttir, María K.; Lund, Sigrún H.; Darreh-Shori, Taher; Snædal, Jón; Petersen, Pétur H. (Springer Science and Business Media LLC, 2020-08-04)
    Background: Neuroinflammation has gained increasing attention as a potential contributing factor in the onset and progression of Alzheimer's disease (AD). The objective of this study was to examine the association of selected cerebrospinal fluid (CSF) ...
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    A Clinical Decision Support System for the Diagnosis, Fracture Risks and Treatment of Osteoporosis 
    Halldórsson, Bjarni; Bjornsson, Aron Hjalti; Guðmundsson, Haukur Týr; Birgisson, Elvar Orn; Ludviksson, Bjorn; Gudbjornsson, Bjorn (Hindawi Limited, 2015)
    Expanding medical knowledge increases the potential risk of medical errors in clinical practice. We present, OPAD, a clinical decision support systemin the field of the medical care of osteoporosis. We utilize clinical information from international ...
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    Clinical decision support system for the management of osteoporosis compared to NOGG guidelines and an osteology specialist: a validation pilot study 
    Guðmundsson, Haukur Týr; Hansen, Karen E.; Halldórsson, Bjarni; Ludviksson, Bjorn; Gudbjornsson, Bjorn (Springer Science and Business Media LLC, 2019-02-01)
    Background: Although osteoporosis is an easily diagnosed and treatable condition, many individuals remain untreated. Clinical decision support systems might increase appropriate treatment of osteoporosis. We designed the Osteoporosis Advisor (OPAD), a ...
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    Current Status and Future Prospects of Genome-Scale Metabolic Modeling to Optimize the Use of Mesenchymal Stem Cells in Regenerative Medicine 
    Sigmarsdóttir, Þóra; McGarrity, Sarah; Rolfsson, Óttar; Yurkovich, James T.; Sigurjónsson, Ólafur E. (Frontiers Media SA, 2020-03-31)
    Mesenchymal stem cells are a promising source for externally grown tissue replacements and patient-specific immunomodulatory treatments. This promise has not yet been fulfilled in part due to production scaling issues and the need to maintain the correct ...
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    DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis 
    Kular, Lara; Liu, Yun; Ruhrmann, Sabrina; Zheleznyakova, Galina; Marabita, Francesco; Gomez-Cabrero, David; James, Tojo; Ewing, Ewoud; Lindén, Magdalena; Górnikiewicz, Bartosz; Aeinehband, Shahin; Stridh, Pernilla; Link, Jenny; Andlauer, Till F. M.; Gasperi, Christiane; Wiendl, Heinz; Zipp, Frauke; Gold, Ralf; Tackenberg, Björn; Weber, Frank; Hemmer, Bernhard; Strauch, Konstantin; Heilmann-Heimbach, Stefanie; Rawal, Rajesh; Schminke, Ulf; Schmidt, Carsten O.; Kacprowski, Tim; Franke, Andre; Laudes, Matthias; Dilthey, Alexander T.; Celius, Elisabeth G.; Søndergaard, Helle B.; Tegnér, Jesper; Harbo, Hanne F.; Oturai, Annette B.; Sigurgeir Ólafsson; Eggertsson, Hannes; Halldórsson, Bjarni; Hjaltason, Haukur; Elías Ólafsson; Jonsdottir, Ingileif; Stefansson, Kari; Olsson, Tomas; Piehl, Fredrik; Ekström, Tomas J.; Kockum, Ingrid; Feinberg, Andrew P.; Jagodic, Maja (Springer Science and Business Media LLC, 2018-06-19)
    The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that DRB1*15:01 is hypomethylated and predominantly expressed in monocytes among carriers of DRB1*15:01. A differentially methylated ...
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    Effects of amotosalen treatment on human platelet lysate bioactivity: A proof-of-concept study 
    Christensen, Christian; Jonsdottir-Buch, Sandra Mjoll; Sigurjonsson, Olafur (Public Library of Science (PLoS), 2020-04-15)
    Background Clinical application of mesenchymal stromal cells (MSCs) usually requires an in vitro expansion step to reach clinically relevant numbers. In vitro cell expansion necessitates supplementation of basal mammalian cell culture medium with growth ...
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    Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis 
    Ólafsdóttir, Þórunn Ásta; Theódórs, Fannar; Bjarnadóttir, Kristbjörg; Björnsdóttir, Unnur Steina; Agustsdottir, Arna B.; Stefánsson, Ólafur A.; Ivarsdottir, Erna; Sigurðsson, Jón K.; Benónísdóttir, Stefanía; Eyjólfsson, Guðmundur I.; Gíslason, Davíð; Gislason, Thorarinn; Guðmundsdóttir, Steinunn; Gylfason, Arnaldur; Halldórsson, Bjarni; Halldorsson, Gisli; Júlíusdóttir, Þórhildur; Kristinsdottir, Anna M.; Lúðvíksdóttir, Dóra; Ludviksson, Bjorn; Másson, Gísli; Norland, Kristjan; Onundarson, Pall; Olafsson, Isleifur; Sigurdardottir, Olof; Stefánsdóttir, Lilja; Sveinbjörnsson, Garðar; Tragante do O, Vinicius; Gudbjartsson, Daniel; Þorleifsson, Guðmar; sulem, patrick; Thorsteinsdottir, Unnur; Norddahl, Guðmundur L.; Jonsdottir, Ingileif; Stefansson, Kari (Springer Science and Business Media LLC, 2020-01-20)
    Asthma is one of the most common chronic diseases affecting both children and adults. We report a genome-wide association meta-analysis of 69,189 cases and 702,199 controls from Iceland and UK biobank. We find 88 asthma risk variants at 56 loci, 19 ...
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    Elucidating dynamic metabolic physiology through network integration of quantitative time-course metabolomics 
    Bordbar, Aarash; Yurkovich, James T.; Paglia, Giuseppe; Rolfsson, Óttar; Sigurjónsson, Ólafur E.; Palsson, Bernhard O. (Springer Nature, 2017-04-07)
    The increasing availability of metabolomics data necessitates novel methods for deeper data analysis and interpretation. We present a flux balance analysis method that allows for the computation of dynamic intracellular metabolic changes at the cellular ...
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    Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank 
    Ólafsdóttir, Thorhildur; Thorleifsson, Gudmar; sulem, patrick; Stefánsson, Ólafur A.; Medek, Helga; Olafsson, Karl; Ingþórsson, Orri; Guðmundsson, Valur; Jonsdottir, Ingileif; Halldorsson, Gisli; Kristjansson, Ragnar; Frigge, Michael L.; Stefánsdóttir, Lilja; Sigurðsson, Jón K.; Oddsson, Asmundur; Sigurðsson, Ásgeir; Eggertsson, Hannes P.; Melsted, Páll; Halldórsson, Bjarni; Lund, Sigrún Helga; Styrkarsdottir, Unnur; Steinthorsdottir, Valgerdur; Gudmundsson, Julius; Holm, Hilma; Tragante do O, Vinicius; Asselbergs, Folkert; Thorsteinsdottir, Unnur; Gudbjartsson, Daniel; Jónsdóttir, Kristín; Rafnar, Thorunn; Stefansson, Kari (Springer Science and Business Media LLC, 2020-03-17)
    Pelvic organ prolapse (POP) is a downward descent of one or more of the pelvic organs, resulting in a protrusion of the vaginal wall and/or uterus. We performed a genome-wide association study of POP using data from Iceland and the UK Biobank, a total ...
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    Human Embryonic-Derived Mesenchymal Progenitor Cells (hES-MP Cells) are Fully Supported in Culture with Human Platelet Lysates 
    Jonsdottir-Buch, Sandra Mjoll; Gunnarsdottir, Kristbjorg; Sigurjonsson, Olafur (MDPI AG, 2020-07-20)
    Human embryonic stem cell-derived mesenchymal progenitor (hES-MP) cells are mesenchymal-like cells, derived from human embryonic stem cells without the aid of feeder cells. They have been suggested as a potential alternative to mesenchymal stromal cells ...
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    Identification of Lynch syndrome risk variants in the Romanian population 
    Iordache, Paul; Mates, Dana; Gunnarsson, Bjarni; Eggertsson, Hannes; sulem, patrick; Benonisdottir, Stefania; Csiki, Irma Eva; Rascu, Stefan; Radavoi, Daniel; Ursu, Radu; Staicu, Catalin; Calota, Violeta; Voinoiu, Angelica; Jinga, Mariana; Rosoga, Gabriel; Danau, Razvan; Sima, Sorin Cristian; Badescu, Daniel; Suciu, Nicoleta; Radoi, Viorica; Mates, Ioan Nicolae; Dobra, Mihai; Nicolae, Camelia; Kristjansdottir, Sigrun; Jónasson, Jón G.; Manolescu, Andrei; Arnadottir, Gudny; Jensson, Brynjar Örn; Jonasdottir, Aslaug; Sigurdsson, Asgeir; le Roux, Louise; Johannsdottir, Hrefna; Rafnar, Thorunn; Halldórsson, Bjarni; Jinga, Viorel; Stefansson, Kari (Wiley, 2018-10-16)
    Two familial forms of colorectal cancer (CRC), Lynch syndrome (LS) and familial adenomatous polyposis (FAP), are caused by rare mutations in DNA mismatch repair genes (MLH1, MSH2, MSH6, PMS2) and the genes APC and MUTYH, respectively. No information ...
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    Long-term outcome of children with autism who received different forms of early intervention during their preschool years: a pilot study of 15 young adults 
    Jónsdóttir, Sigrídur Lóa; Brynjarsdóttir, Birta; Sæmundsen, Evald E.; Sigurðsson, Jón Friðrik (Exeley, Inc., 2018)
    Background: Studies on early intervention have reported significant gains for many children with autism. Knowledge on how these children fare in adulthood is limited. Objective: To examine long-term outcome of children with autism who received ...
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    Maternal smoking during pregnancy and scholastic achievement in childhood: evidence from the LIFECOURSE cohort study 
    Kristjansson, Alfgeir; Þórisdóttir, Ingibjörg E.; Steingrimsdottir, Thora; Allegrante, John; Lilly, Christa L.; Sigfúsdóttir, Inga Dóra (Oxford University Press (OUP), 2017-05-28)
    Research on the impact of maternal smoking during pregnancy (MSDP) on scholastic achievement in the offspring has shown conflicting findings. The objective of this study was to assess the impact of MSDP on scholastic achievement in a birth cohort of ...
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    Obesity modulates the association between sleep apnea treatment and CHI3L1 levels but not CHIT1 activity in moderate to severe OSA: an observational study 
    Teitsdóttir, Unnur Diljá; Arnardottir, Erna Sif; Björnsdóttir, Erla; Gislason, Thorarinn; Petersen, Petur Henry (Springer Nature, 2018-10-11)
    Purpose The inflammatory markers chitinase-3-like protein 1 (CHI3L1) and chitotriosidase (CHIT1) have both been associated with cardiovascular complications. The aim of this preliminary observational study was to assess the roles and interaction ...
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    Profile of common prostate cancer risk variants in an unscreened Romanian population 
    Iordache, Paul; Mates, Dana; Gunnarsson, Bjarni; Eggertsson, Hannes; sulem, patrick; Guðmundsson, Júlíus; Benonisdottir, Stefania; Csiki, Irma Eva; Rascu, Stefan; Radavoi, Daniel; Ursu, Radu; Staicu, Catalin; Calota, Violeta; Voinoiu, Angelica; Jinga, Mariana; Rosoga, Gabriel; Danau, Razvan; Sima, Sorin Cristian; Badescu, Daniel; Suciu, Nicoleta; Radoi, Viorica; Manolescu, Andrei; Rafnar, Thorunn; Halldórsson, Bjarni; Jinga, Viorel; Stefansson, Kari (Wiley, 2017-12-20)
    To find sequence variants affecting prostate cancer (PCA) susceptibility in an unscreened Romanian population we use a genome‐wide association study (GWAS). The study population included 990 unrelated pathologically confirmed PCA cases and 1034 male ...
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    A randomized controlled trial reporting functional outcomes of cognitive–behavioural therapy in medication-treated adults with ADHD and comorbid psychopathology 
    Young, Susan; Emilsson, Brynjar; Sigurdsson, Jon Fridrik; Khondoker, Mizanur; Philipp-Wiegmann, Florence; Baldursson, Gísli; Ólafsdóttir, Halldóra; Gudjonsson, Gisli (Springer Nature, 2016-10-17)
    Studies assessing psychological treatment of attention deficit hyperactivity disorder (ADHD) in adults are increasingly reported. However, functional outcomes are often neglected in favour of symptom outcomes. We investigated functional outcomes in 95 ...