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Browsing Greinar- HÍ by Subject "Cyclodextrin"

Browsing Greinar- HÍ by Subject "Cyclodextrin"

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    Cytotoxicity of β-Cyclodextrins in Retinal Explants for Intravitreal Drug Formulations 
    Prajapati, Manisha; Christensen, Gustav; Paquet-Durand, Francois; Loftsson, Thorsteinn (MBPI, 2021-03)
    Cyclodextrins (CDs) have been widely used as pharmaceutical excipients for formulation purposes for different delivery systems. Recent studies have shown that CDs are able to form complexes with a variety of biomolecules, such as cholesterol. This has ...
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    In Vitro and Ex Vivo Evaluation of Nepafenac-Based Cyclodextrin Microparticles for Treatment of Eye Inflammation 
    Lorenzo Veiga, Blanca; Diaz-Rodriguez, Patricia; Alvarez-Lorenzo, Carmen; Loftsson, Thorsteinn; Sigurdsson, Hakon Hrafn (MDPI AG, 2020-04-09)
    The aim of this study was to design and evaluate novel cyclodextrin (CD)-based aggregate formulations to efficiently deliver nepafenac topically to the eye structure, to treat inflammation and increase nepafenac levels in the posterior segment, thus ...
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    Nepafenac-Loaded Cyclodextrin/Polymer Nanoaggregates: A New Approach to Eye Drop Formulation 
    Lorenzo Veiga, Blanca; Sigurdsson, Hakon Hrafn; Loftsson, Thorsteinn (MDPI AG, 2019-01-11)
    The topical administration route is commonly used for targeting therapeutics to the eye; however, improving the bioavailability of drugs applied directly to the eye remains a challenge. Different strategies have been studied to address this challenge. ...
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    Solubility of Cyclodextrins and Drug/Cyclodextrin Complexes 
    Saokham, Phennapha; Muankaew, Chutimon; Jansook, Phatsawee; Loftsson, Thorsteinn (MDPI AG, 2018-05-11)
    Cyclodextrins (CDs), a group of oligosaccharides formed by glucose units bound together in a ring, show a promising ability to form complexes with drug molecules and improve their physicochemical properties without molecular modifications. The stoichiometry ...