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Geographical variation in lung function : Results from the multicentric cross-sectional BOLD study

Geographical variation in lung function : Results from the multicentric cross-sectional BOLD study


Title: Geographical variation in lung function : Results from the multicentric cross-sectional BOLD study
Author: Burney, Peter G.J.
Potts, James
Knox-Brown, Ben
Erhabor, Gregory
Hacene Cherkaski, Hamid
Mortimer, Kevin
Anand, Mahesh Padukudru
Mannino, David M.
Cardoso, Joao
Ahmed, Rana
... 25 more authors Show all authors
Date: 2025-12-31
Language: English
Scope: 1
University/Institute: Landspitali - The National University Hospital of Iceland
Department: Faculty of Medicine
Series: Pulmonology; 31(1)
ISSN: 2531-0429
DOI: 10.1080/25310429.2024.2430491
Subject: Lungnalæknisfræði; airflow obstruction; Cross-sectional studies; forced expiratory volume; forced vital capacity; global health; Pulmonary and Respiratory Medicine
URI: https://hdl.handle.net/20.500.11815/5303

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Citation:

Burney , P G J , Potts , J , Knox-Brown , B , Erhabor , G , Hacene Cherkaski , H , Mortimer , K , Anand , M P , Mannino , D M , Cardoso , J , Ahmed , R , Elsony , A , Barbara , C , Nielsen , R , Bateman , E , Paraguas , S N M , Cher Loh , L , Rashid , A , Wouters , E F , Franssen , F M , Dias , H B , Gíslason , Þ , Ghobain , M A , Biaze , M E , Agarwal , D , Juvekar , S , Rodrigues , F , Obaseki , D O , Koul , P A , Harrabi , I , Nafees , A A , Seemungal , T , Janson , C , Vollmer , W M , Amaral , A F & Buist , A S 2025 , ' Geographical variation in lung function : Results from the multicentric cross-sectional BOLD study ' , Pulmonology , vol. 31 , no. 1 , pp. 2430491 . https://doi.org/10.1080/25310429.2024.2430491

Abstract:

Spirometry is used to determine what is "unusual" lung function compared with what is "usual" for healthy non-smokers. This study aimed to investigate regional variation in the forced vital capacity (FVC) and in the forced expiratory volume in one second to FVC ratio (FEV1/FVC) using cross-sectional data from all 41 sites of the multinational Burden of Obstructive Lung Disease study. Participants (5,368 men; 9,649 women), aged ≥40 years, had performed spirometry, had never smoked and reported no respiratory symptoms or diagnoses. To identify regions with similar FVC, we conducted a principal component analysis (PCA) on FVC with age, age2 and height2, separately for men and women. We regressed FVC against age, age2 and height2, and FEV1/FVC against age and height2, for each sex and site, stratified by region. Mean age was 54 years (both sexes), and mean height was 1.69 m (men) and 1.61 m (women). The PCA suggested four regions: 1) Europe and richer countries; 2) the Near East; 3) Africa; and 4) the Far East. For the FVC, there was little variation in the coefficients for age, or age2, but considerable variation in the constant (men: 2.97 L in the Far East to 4.08 L in Europe; women: 2.44 L in the Far East to 3.24 L in Europe) and the coefficient for height2. Regional differences in the constant and coefficients for FEV1/FVC were minimal (<1%). The relation of FVC with age, sex and height varies across and within regions. The same is not true for the FEV1/FVC ratio.

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