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Prokinetic agents in adult intensive care unit patients (PATIENCE)—An international inception cohort study protocol

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dc.contributor.author Crone, Vera
dc.contributor.author Møller, Morten Hylander
dc.contributor.author Perner, Anders
dc.contributor.author Alhazzani, Waleed
dc.contributor.author Granholm, Anders
dc.contributor.author Krogsgaard, Laura Rindom
dc.contributor.author Al-Fares, Abdulrahman
dc.contributor.author Hästbacka, Johanna
dc.contributor.author Ostermann, Marlies
dc.contributor.author Pfortmueller, Carmen A.
dc.contributor.author Ferrer, Richard
dc.contributor.author Blaser, Annika Reintam
dc.contributor.author Sigurðsson, Martin Ingi
dc.contributor.author Wall, Olof
dc.contributor.author Keus, Eric
dc.contributor.author Szczeklik, Wojciech
dc.contributor.author Krag, Mette
dc.date.accessioned 2024-12-07T01:03:46Z
dc.date.available 2024-12-07T01:03:46Z
dc.date.issued 2024-11
dc.identifier.citation Crone , V , Møller , M H , Perner , A , Alhazzani , W , Granholm , A , Krogsgaard , L R , Al-Fares , A , Hästbacka , J , Ostermann , M , Pfortmueller , C A , Ferrer , R , Blaser , A R , Sigurðsson , M I , Wall , O , Keus , E , Szczeklik , W & Krag , M 2024 , ' Prokinetic agents in adult intensive care unit patients (PATIENCE)—An international inception cohort study protocol ' , Acta anaesthesiologica Scandinavica , vol. 68 , no. 10 , pp. 1601-1606 . https://doi.org/10.1111/aas.14534
dc.identifier.issn 0001-5172
dc.identifier.other 230525777
dc.identifier.other 4bd0c4aa-c30a-4610-bb06-f6fe02a17644
dc.identifier.other 85205468445
dc.identifier.other 39350471
dc.identifier.uri https://hdl.handle.net/20.500.11815/5159
dc.description Publisher Copyright: © 2024 The Author(s). Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.
dc.description.abstract Background: Feeding intolerance is common in critically ill patients and can lead to malnutrition. Prokinetic agents may be used to enhance the uptake of nutrition. However, the evidence on the effectiveness and safety of prokinetic agents is sparse, and there is a lack of data on their use in intensive care units (ICU). Methods: We will conduct an international 14-day inception cohort study of 1000 acutely admitted adult ICU patients. Data will be collected from ICU admission and daily during ICU stay for up to 90 days. The primary outcome will be the proportion of ICU patients who receive prokinetic agents. Secondary outcomes include mortality, days alive without life support, days alive out of ICU, days alive out of hospital (all within 90 days) and the number of patients with one or more serious adverse events. Results: We will present data on the use of prokinetic agents descriptively and use Cox regressions with death and ICU discharge as competing events to evaluate the association between patient characteristics and the use of prokinetic agents. We will use extended Cox models with time-varying covariates and linear regression models to assess the associations between the use of prokinetic agents and the secondary outcomes. Conclusion: The outlined international cohort study will provide valuable epidemiological data on the use of prokinetic agents in adult, acutely admitted ICU patients.
dc.format.extent 6
dc.format.extent 552751
dc.format.extent 1601-1606
dc.language.iso en
dc.relation.ispartofseries Acta anaesthesiologica Scandinavica; 68(10)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Svæfinga- og gjörgæslulæknisfræði
dc.subject cohort study
dc.subject intensive care
dc.subject prokinetic agents
dc.subject protocol
dc.subject Anesthesiology and Pain Medicine
dc.subject SDG 2 - Zero Hunger
dc.title Prokinetic agents in adult intensive care unit patients (PATIENCE)—An international inception cohort study protocol
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.doi 10.1111/aas.14534
dc.relation.url http://www.scopus.com/inward/record.url?scp=85205468445&partnerID=8YFLogxK
dc.contributor.department Other departments
dc.contributor.department Faculty of Medicine


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