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Changes in body mass index during treatment of childhood acute lymphoblastic leukemia with the Nordic ALL2008 protocol

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author Egnell, Christina
dc.contributor.author Närhinen, Hanna
dc.contributor.author Merker, Andrea
dc.contributor.author Jónsson, Ólafur Gísli
dc.contributor.author Lepik, Kristi
dc.contributor.author Niinimäki, Riitta
dc.contributor.author Schmiegelow, Kjeld
dc.contributor.author Stabell, Niklas
dc.contributor.author Klug Albertsen, Birgitte
dc.contributor.author Vaitkeviciene, Goda
dc.contributor.author Ranta, Susanna
dc.contributor.author Harila-Saari, Arja
dc.date.accessioned 2023-02-25T01:06:24Z
dc.date.available 2023-02-25T01:06:24Z
dc.date.issued 2022-12
dc.identifier.citation Egnell , C , Närhinen , H , Merker , A , Jónsson , Ó G , Lepik , K , Niinimäki , R , Schmiegelow , K , Stabell , N , Klug Albertsen , B , Vaitkeviciene , G , Ranta , S & Harila-Saari , A 2022 , ' Changes in body mass index during treatment of childhood acute lymphoblastic leukemia with the Nordic ALL2008 protocol ' , European Journal of Haematology , vol. 109 , no. 6 , pp. 656-663 . https://doi.org/10.1111/ejh.13848
dc.identifier.issn 0902-4441
dc.identifier.other PURE: 95550129
dc.identifier.other PURE UUID: e72ac948-c61e-4994-b67a-d4e5f09901ef
dc.identifier.other Scopus: 85137553262
dc.identifier.uri https://hdl.handle.net/20.500.11815/4038
dc.description Funding Information: Christina Egnell is supported by funding from the Swedish Childhood Cancer Foundation (Barncancerfonden, grant numbers TJ2018‐0093; PR2019‐0075; TJ2019‐0048). This work is part of the Danish nation‐wide research program Childhood Oncology Network Targeting Research, Organisation & Life expectancy (CONTROL) and supported by the Danish Cancer Society (R‐257‐A14720) and the Danish Childhood Cancer Foundation (2019‐5934 and 2020‐5769). Publisher Copyright: © 2022 The Authors. European Journal of Haematology published by John Wiley & Sons Ltd.
dc.description.abstract Objectives: Children with acute lymphoblastic leukemia (ALL) have a tendency to gain weight during treatment. As overweight and obesity associate with health problems, prophylactic interventions are warranted. Therefore, it is important to identify the children most prone to gain weight. Methods: Patients aged 2.0–17.9 years at ALL diagnosis were identified from the NOPHO ALL2008 registry. Registry data was complemented with height and weight at the end of therapy from questionnaires. Body mass index (BMI) was classified according to international age- and sex-adjusted International Obesity Task Force BMI cut-offs. BMI values were transformed into standard deviation scores (SDS) to calculate the difference in BMISDS during treatment. Results: Data on BMI change were available for 765 children. Overweight and obesity doubled during treatment: 9.7% were overweight and 2.1% obese at diagnosis and 21.8% and 5.4% at the end of therapy, respectively. The mean BMISDS change was +0.64. Younger (2.0–5.9 years) and healthy weight children were most prone to become overweight (mean change in BMI SDS +0.85 and + 0.65, respectively). Conclusions: Younger children (2.0–5.9 years) with healthy weight at diagnosis were most prone to becoming overweight and therefore are an important group to target while considering interventions.
dc.format.extent 8
dc.format.extent 656-663
dc.language.iso en
dc.relation.ispartofseries European Journal of Haematology; 109(6)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Barnalæknisfræði
dc.subject acute lymphoblastic leukemia
dc.subject body mass index
dc.subject children
dc.subject obesity
dc.subject overweight
dc.subject support care
dc.subject Hematology
dc.title Changes in body mass index during treatment of childhood acute lymphoblastic leukemia with the Nordic ALL2008 protocol
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 36006839
dc.identifier.doi https://doi.org/10.1111/ejh.13848
dc.relation.url http://www.scopus.com/inward/record.url?scp=85137553262&partnerID=8YFLogxK

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