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HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2

HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2


Title: HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2
Author: Olafsdottir, Thorunn A
Bjarnadottir, Kristbjorg
Norddahl, Gudmundur L.
Halldórsson, Gísli Hreinn
Melsted, Páll   orcid.org/0000-0002-8418-6724
Gunnarsdottir, Kristbjorg
Ivarsdottir, Erna   orcid.org/0000-0002-2069-0681
Olafsdottir, Thorhildur
Arnthorsson, Asgeir O
Theodors, Fannar
... 21 more authors Show all authors
Date: 2022-09-06
Language: English
Scope: 914
University/Institute: Landspitali - The National University Hospital of Iceland
Reykjavik University
School: Health Sciences
Department: Faculty of Industrial Engineering, Mechanical Engineering and Computer Science
Faculty of Medicine
Internal Medicine and Emergency Services
Clinical Laboratory Services, Diagnostics and Blood Bank
Other departments
Office of Division of Clinical Services I
Series: Communications Biology; 5(1)
ISSN: 2399-3642
DOI: https://doi.org/10.1038/s42003-022-03893-w
Subject: Nýrnalæknisfræði; Smitsjúkdómalæknisfræði; Lífefna- og sameindalíffræði; Svæfinga- og gjörgæslulæknisfræði; Alleles; CD8-Positive T-Lymphocytes; COVID-19/genetics; Humans; SARS-CoV-2; Severity of Illness Index
URI: https://hdl.handle.net/20.500.11815/3462

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Citation:

Olafsdottir , T A , Bjarnadottir , K , Norddahl , G L , Halldórsson , G H , Melsted , P , Gunnarsdottir , K , Ivarsdottir , E , Olafsdottir , T , Arnthorsson , A O , Theodors , F , Eyþórsson , E S , Helgason , D , Eggertsson , H P , Masson , G , Bjarnadottir , S , Sævarsdóttir , S , Runólfsdóttir , H L , Ólafsson , Í , Saemundsdottir , J , Sigurdsson , M I , Ingvarsson , R F , Pálsson , R , Thorgeirsson , G , Halldórsson , B V , Holm , H , Kristjánsson , M , Sulem , P , Þorsteinsdóttir , U , Jónsdóttir , I , Gudbjartsson , D F & Stefansson , K 2022 , ' HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2 ' , Communications Biology , vol. 5 , no. 1 , pp. 914 . https://doi.org/10.1038/s42003-022-03893-w

Abstract:

Memory T-cell responses following SARS-CoV-2 infection have been extensively investigated but many studies have been small with a limited range of disease severity. Here we analyze SARS-CoV-2 reactive T-cell responses in 768 convalescent SARS-CoV-2-infected (cases) and 500 uninfected (controls) Icelanders. The T-cell responses are stable three to eight months after SARS-CoV-2 infection, irrespective of disease severity and even those with the mildest symptoms induce broad and persistent T-cell responses. Robust CD4+ T-cell responses are detected against all measured proteins (M, N, S and S1) while the N protein induces strongest CD8+ T-cell responses. CD4+ T-cell responses correlate with disease severity, humoral responses and age, whereas CD8+ T-cell responses correlate with age and functional antibodies. Further, CD8+ T-cell responses associate with several class I HLA alleles. Our results, provide new insight into HLA restriction of CD8+ T-cell immunity and other factors contributing to heterogeneity of T-cell responses following SARS-CoV-2 infection.

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© 2022. The Author(s).

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