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Breast cancer survival in Nordic BRCA2 mutation carriers—unconventional association with oestrogen receptor status

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author Olafsdottir, Elinborg J.
dc.contributor.author Borg, Ake
dc.contributor.author Jensen, Maj Britt
dc.contributor.author Gerdes, Anne Marie
dc.contributor.author Johansson, Anna L.V.
dc.contributor.author Barkardottir, Rosa B.
dc.contributor.author Johannsson, Oskar T.
dc.contributor.author Ejlertsen, Bent
dc.contributor.author Sønderstrup, Ida Marie Heeholm
dc.contributor.author Hovig, Eivind
dc.contributor.author Lænkholm, Anne Vibeke
dc.contributor.author Hansen, Thomas van Overeem
dc.contributor.author Olafsdottir, Gudridur H.
dc.contributor.author Rossing, Maria
dc.contributor.author Jonasson, Jon G.
dc.contributor.author Sigurdsson, Stefan
dc.contributor.author Loman, Niklas
dc.contributor.author Nilsson, Martin P.
dc.contributor.author Narod, Steven A.
dc.contributor.author Tryggvadottir, Laufey
dc.date.accessioned 2022-08-27T01:02:02Z
dc.date.available 2022-08-27T01:02:02Z
dc.date.issued 2020-11-24
dc.identifier.citation Olafsdottir , E J , Borg , A , Jensen , M B , Gerdes , A M , Johansson , A L V , Barkardottir , R B , Johannsson , O T , Ejlertsen , B , Sønderstrup , I M H , Hovig , E , Lænkholm , A V , Hansen , T V O , Olafsdottir , G H , Rossing , M , Jonasson , J G , Sigurdsson , S , Loman , N , Nilsson , M P , Narod , S A & Tryggvadottir , L 2020 , ' Breast cancer survival in Nordic BRCA2 mutation carriers—unconventional association with oestrogen receptor status ' , British Journal of Cancer , vol. 123 , no. 11 , pp. 1608-1615 . https://doi.org/10.1038/s41416-020-01056-4
dc.identifier.issn 0007-0920
dc.identifier.other PURE: 37679177
dc.identifier.other PURE UUID: ae63b436-4d74-458f-97d6-f5361fe55bc2
dc.identifier.other Scopus: 85091156088
dc.identifier.uri https://hdl.handle.net/20.500.11815/3382
dc.description Publisher Copyright: © 2020, The Author(s), under exclusive licence to Cancer Research UK.
dc.description.abstract Background: The natural history of breast cancer among BRCA2 carriers has not been clearly established. In a previous study from Iceland, positive ER status was a negative prognostic factor. We sought to identify factors that predicted survival after invasive breast cancer in an expanded cohort of BRCA2 carriers. Methods: We studied 608 women with invasive breast cancer and a pathogenic BRCA2 mutation (variant) from four Nordic countries. Information on prognostic factors and treatment was retrieved from health records and by analysis of archived tissue specimens. Hazard ratios (HR) were estimated for breast cancer-specific survival using Cox regression. Results: About 77% of cancers were ER-positive, with the highest proportion (83%) in patients under 40 years. ER-positive breast cancers were more likely to be node-positive (59%) than ER-negative cancers (34%) (P < 0.001). The survival analysis included 584 patients. Positive ER status was protective in the first 5 years from diagnosis (multivariate HR = 0.49; 95% CI 0.26–0.93, P = 0.03); thereafter, the effect was adverse (HR = 1.91; 95% CI 1.07–3.39, P = 0.03). The adverse effect of positive ER status was limited to women who did not undergo endocrine treatment (HR = 2.36; 95% CI 1.26–4.44, P = 0.01) and patients with intact ovaries (HR = 1.99; 95% CI 1.11–3.59, P = 0.02). Conclusions: The adverse effect of a positive ER status in BRCA2 carriers with breast cancer may be contingent on exposure to ovarian hormones.
dc.format.extent 8
dc.format.extent 1608-1615
dc.language.iso en
dc.relation.ispartofseries British Journal of Cancer; 123(11)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Oncology
dc.subject Cancer Research
dc.title Breast cancer survival in Nordic BRCA2 mutation carriers—unconventional association with oestrogen receptor status
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 32939053
dc.identifier.doi https://doi.org/10.1038/s41416-020-01056-4
dc.relation.url http://www.scopus.com/inward/record.url?scp=85091156088&partnerID=8YFLogxK
dc.contributor.department Clinical Laboratory Services, Diagnostics and Blood Bank
dc.contributor.department Faculty of Medicine

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