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Acute COVID-19 severity and mental health morbidity trajectories in patient populations of six nations : an observational study

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dc.contributor.author COVIDMENT Collaboration
dc.date.accessioned 2022-08-24T01:03:16Z
dc.date.available 2022-08-24T01:03:16Z
dc.date.issued 2022-05
dc.identifier.citation COVIDMENT Collaboration 2022 , ' Acute COVID-19 severity and mental health morbidity trajectories in patient populations of six nations : an observational study ' , The Lancet Public Health , vol. 7 , no. 5 , pp. e406-e416 . https://doi.org/10.1016/S2468-2667(22)00042-1
dc.identifier.issn 2468-2667
dc.identifier.other PURE: 51804285
dc.identifier.other PURE UUID: a5288f80-3917-436c-a5d1-9e997dabb088
dc.identifier.other PubMedCentral: PMC8920517
dc.identifier.other Scopus: 85129781421
dc.identifier.uri https://hdl.handle.net/20.500.11815/3340
dc.description Funding Information: This work was supported by grants from Canadian Institutes of Health Research (IRSC) and Fonds de la Recherche en Santé du Québec (FRSQ). Publisher Copyright: Copyright © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights reserved.
dc.description.abstract BACKGROUND: Long-term mental and physical health consequences of COVID-19 (long COVID) are a persistent public health concern. Little is still known about the long-term mental health of non-hospitalised patients with COVID-19 with varying illness severities. Our aim was to assess the prevalence of adverse mental health symptoms among individuals diagnosed with COVID-19 in the general population by acute infection severity up to 16 months after diagnosis. METHODS: This observational follow-up study included seven prospectively planned cohorts across six countries (Denmark, Estonia, Iceland, Norway, Sweden, and the UK). Participants were recruited from March 27, 2020, to Aug 13, 2021. Individuals aged 18 years or older were eligible to participate. In a cross-sectional analysis, we contrasted symptom prevalence of depression, anxiety, COVID-19-related distress, and poor sleep quality (screened with validated mental health instruments) among individuals with and without a diagnosis of COVID-19 at entry, 0-16 months from diagnosis. In a cohort analysis, we further used repeated measures to estimate the change in mental health symptoms before and after COVID-19 diagnosis. FINDINGS: The analytical cohort consisted of 247 249 individuals, 9979 (4·0%) of whom were diagnosed with COVID-19 during the study period. Mean follow-up was 5·65 months (SD 4·26). Participants diagnosed with COVID-19 presented overall with a higher prevalence of symptoms of depression (prevalence ratio [PR] 1·18 [95% CI 1·03-1·36]) and poorer sleep quality (1·13 [1·03-1·24]) but not symptoms of anxiety (0·97 [0·91-1·03]) or COVID-19-related distress (1·05 [0·93-1·20]) compared with individuals without a COVID-19 diagnosis. Although the prevalence of depression and COVID-19-related distress attenuated with time, individuals diagnosed with COVID-19 but never bedridden due to their illness were consistently at lower risk of depression (PR 0·83 [95% CI 0·75-0·91]) and anxiety (0·77 [0·63-0·94]) than those not diagnosed with COVID-19, whereas patients who were bedridden for more than 7 days were persistently at higher risk of symptoms of depression (PR 1·61 [95% CI 1·27-2·05]) and anxiety (1·43 [1·26-1·63]) than those not diagnosed throughout the study period. INTERPRETATION: Severe acute COVID-19 illness-indicated by extended time bedridden-is associated with long-term mental morbidity among recovering individuals in the general population. These findings call for increased vigilance of adverse mental health development among patients with a severe acute disease phase of COVID-19. FUNDING: Nordforsk, Horizon2020, Wellcome Trust, and Estonian Research Council.
dc.format.extent e406-e416
dc.language.iso en
dc.relation.ispartofseries The Lancet Public Health; 7(5)
dc.rights info:eu-repo/semantics/openAccess
dc.subject COVID-19/complications
dc.subject COVID-19 Testing
dc.subject Cross-Sectional Studies
dc.subject Follow-Up Studies
dc.subject Humans
dc.subject Mental Health
dc.subject Morbidity
dc.subject Covid-19
dc.subject Geðheilsa
dc.subject Public Health, Environmental and Occupational Health
dc.title Acute COVID-19 severity and mental health morbidity trajectories in patient populations of six nations : an observational study
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 35298894
dc.identifier.doi https://doi.org/10.1016/S2468-2667(22)00042-1
dc.relation.url http://www.scopus.com/inward/record.url?scp=85129781421&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine


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