dc.contributor.author |
Fatty Acids and Outcomes Research Consortium (FORCE) |
dc.date.accessioned |
2022-06-01T01:01:53Z |
dc.date.available |
2022-06-01T01:01:53Z |
dc.date.issued |
2021-04-22 |
dc.identifier.citation |
Fatty Acids and Outcomes Research Consortium (FORCE) 2021 , ' Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies ' , Nature Communications , vol. 12 , no. 1 , 2329 , pp. 2329 . https://doi.org/10.1038/s41467-021-22370-2 |
dc.identifier.issn |
2041-1723 |
dc.identifier.other |
38444603 |
dc.identifier.other |
e407b524-525e-4733-9e26-10a148042720 |
dc.identifier.other |
85105757201 |
dc.identifier.other |
33888689 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/3208 |
dc.description |
Funding Information: The authors below declare the following competing interests outside of the submitted work. A.I.B., Involvement in a research project partly funded by Unilever. A.S.V., Grants and support to attend professional meetings from the California Walnut Commission. B. M.P., Data and Safety Monitoring Board of a clinical trial funded by Zoll LifeCor; Steering Committee of the Yale Open Data Access Project funded by Johnson & Johnson. D.M., Research grants to Institution: the National Institutes of Health, the Gates Foundation, and the Rockefeller Foundation; Personal Fees: the Global Organization for EPA and DHA Omega-3, Bunge, Indigo Agriculture, Motif FoodWorks, Amarin, Acasti Pharma, Cleveland Clinic Foundation, Danone, and America’s Test Kitchen; Scientific Advisory Boards: Brightseed, Calibrate, DayTwo, Elysium Health, Filtricine, Foodome, Human Co., and Tiny Organics; and Chapter Royalties: UpToDate. J.G.R., Research grants to Institution: Acasti, Amarin, Amgen, Astra-Zeneca, Eli Lilly, Esperion, Medicines Company, Merck, Novartis, Novo-Nordisk, Regeneron, and Sanofi. Consultant: Getz Pharma, Medicines Company, and Sanofi. R.A.M., Research grants to Institution: I. L.S.I. North America; Personal Fees from PharmaVite. The author below declares the following competing interests related to the submitted work. W.S.H., Stock in Omega-Quant Analytics, LLC (a laboratory that offers blood fatty acid testing); Schiff Institute Science and Innovation Advisory Board. The remaining authors declare no competing interests. Publisher Copyright: © 2021, The Author(s). |
dc.description.abstract |
The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15-18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death. |
dc.format.extent |
1 |
dc.format.extent |
1285210 |
dc.format.extent |
2329 |
dc.language.iso |
en |
dc.relation.ispartofseries |
Nature Communications; 12(1) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Dánarmein |
dc.subject |
Fjölómettaðar fitusýrur |
dc.subject |
Mortality, Premature |
dc.subject |
Fatty Acids, Omega-3 / blood |
dc.subject |
Cause of Death |
dc.subject |
General Chemistry |
dc.subject |
General Biochemistry,Genetics and Molecular Biology |
dc.subject |
General Physics and Astronomy |
dc.title |
Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies |
dc.type |
/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version |
Peer reviewed |
dc.identifier.doi |
10.1038/s41467-021-22370-2 |
dc.relation.url |
http://www.scopus.com/inward/record.url?scp=85105757201&partnerID=8YFLogxK |
dc.contributor.department |
Faculty of Medicine |