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Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author International Headache Genetics Consortium
dc.contributor.author HUNT All-in Headache
dc.contributor.author Danish Blood Donor Study Genomic Cohort
dc.date.accessioned 2022-04-07T01:02:11Z
dc.date.available 2022-04-07T01:02:11Z
dc.date.issued 2022-02
dc.identifier.citation International Headache Genetics Consortium , HUNT All-in Headache & Danish Blood Donor Study Genomic Cohort 2022 , ' Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles ' , Nature Genetics , vol. 54 , no. 2 , pp. 152-160 . https://doi.org/10.1038/s41588-021-00990-0
dc.identifier.issn 1061-4036
dc.identifier.other PURE: 46887295
dc.identifier.other PURE UUID: 422bc099-92e0-4953-8829-d0416008242e
dc.identifier.other Scopus: 85124577579
dc.identifier.uri https://hdl.handle.net/20.500.11815/3029
dc.description Publisher Copyright: © 2022. The Author(s).
dc.description.abstract Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified 123 loci, of which 86 are previously unknown. These loci provide an opportunity to evaluate shared and distinct genetic components in the two main migraine subtypes: migraine with aura and migraine without aura. Stratification of the risk loci using 29,679 cases with subtype information indicated three risk variants that seem specific for migraine with aura (in HMOX2, CACNA1A and MPPED2), two that seem specific for migraine without aura (near SPINK2 and near FECH) and nine that increase susceptibility for migraine regardless of subtype. The new risk loci include genes encoding recent migraine-specific drug targets, namely calcitonin gene-related peptide (CALCA/CALCB) and serotonin 1F receptor (HTR1F). Overall, genomic annotations among migraine-associated variants were enriched in both vascular and central nervous system tissue/cell types, supporting unequivocally that neurovascular mechanisms underlie migraine pathophysiology.
dc.format.extent 9
dc.format.extent 152-160
dc.language.iso en
dc.relation.ispartofseries Nature Genetics; 54(2)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Taugasjúkdómafræði
dc.subject Mígreni
dc.subject Genarannsóknir
dc.subject Gen
dc.subject Migraine Disorders
dc.subject Genetic Predisposition to Disease
dc.subject Genome-Wide Association Study
dc.subject Genetics
dc.title Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 35115687
dc.identifier.doi https://doi.org/10.1038/s41588-021-00990-0
dc.relation.url http://www.scopus.com/inward/record.url?scp=85124577579&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine


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