dc.contributor.author |
Bengtsson, Boel |
dc.contributor.author |
Lindén, Christina |
dc.contributor.author |
Heijl, Anders |
dc.contributor.author |
Andersson-Geimer, Sabina |
dc.contributor.author |
Aspberg, Johan |
dc.contributor.author |
Jóhannesson, Gauti |
dc.date.accessioned |
2022-01-15T01:02:32Z |
dc.date.available |
2022-01-15T01:02:32Z |
dc.date.issued |
2021-07-29 |
dc.identifier.citation |
Bengtsson , B , Lindén , C , Heijl , A , Andersson-Geimer , S , Aspberg , J & Jóhannesson , G 2021 , ' The glaucoma intensive treatment study : interim results from an ongoing longitudinal randomized clinical trial ' , Acta Ophthalmologica . https://doi.org/10.1111/aos.14978 |
dc.identifier.issn |
1755-375X |
dc.identifier.other |
42893591 |
dc.identifier.other |
0c82d718-e092-48f8-962a-796f802741fc |
dc.identifier.other |
85111523268 |
dc.identifier.other |
unpaywall: 10.1111/aos.14978 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/2833 |
dc.description |
Funding text Financial support was provided through regional agreements between Lund University and Skane Regional Council (ALF), and between Umea University and V€asterbotten County Council and also by grants from the Swedish Society for medical research, Knut and Alice Wallenbergs foundation, Cronqvist foundation, € Ogonfonden, Swedish medical society foundation, Foundation for visually impaired in former Malm€ohus county, King Gustav V and Queen Victoria’s freemason foundation, foundations and donations administered by Skane University Hospital, Crown Princess Margareta´s foundation, Margit and Kjell Stolz Foundation, Herman J€arnhardt foundation, Ingrid Nordmark’s foundation and Insamlingsstiftelserna vid Umea universitet. None of the supporting organizations had any role in the design or conduct of the research. Publisher Copyright: © 2021 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation. |
dc.description.abstract |
Purpose: The aim of the study was to determine the perimetric rate of glaucoma progression in the ongoing Glaucoma Intensive Treatment Study (GITS) after 3 years of follow-up. Design: This is a randomized, two-centre, prospective open-labelled treatment trial for open-angle glaucoma (OAG). Participants: The participants of this study were treatment-naive patients with newly diagnosed OAG, aged 46–78 years, with early to moderate glaucomatous visual field loss scheduled to be followed for 5 years within the study. Methods: Patients were randomized to initial treatment with either topical monotherapy or with an intensive approach using drugs from three different classes, plus 360° laser trabeculoplasty. Changes in treatment were allowed. Standard automated perimetry and tonometry were performed and side-effects documented. All results are presented using intention-to-treat analysis. Results: A total of 242 patients were randomized. After 3 years of follow-up, eight patients were lost to follow-up, six of whom were deceased. The median untreated baseline intraocular pressure (IOP) was 24 mmHg in both arms. The median IOP was almost constant over the 3 years of follow-up: ≈17 mmHg in the mono-arm and ≈14 mmHg in the multi-treatment arm. Treatment was intensified in 42% of the mono-treated patients and in 7% of the multi-treated patients. Treatment was reduced in 13% of the multi-treated patients. The median perimetric rate of progression was −0.5%/year in the mono-treated group and −0.1%/year in the multi-treated group (p = 0.03). Conclusion: The rate of disease progression was significantly slower in the multi-treated patients than in the mono-treated patients. Further follow-up will show whether this difference is sustained over time. |
dc.format.extent |
328201 |
dc.format.extent |
|
dc.language.iso |
en |
dc.relation.ispartofseries |
Acta Ophthalmologica; () |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Gláka |
dc.subject |
Lyf |
dc.subject |
Prófanir |
dc.subject |
Samanburðarrannsóknir |
dc.subject |
Augnsjúkdómar |
dc.subject |
drug trial |
dc.subject |
glaucoma |
dc.subject |
progression |
dc.subject |
RCT |
dc.subject |
visual field |
dc.subject |
Ophthalmology |
dc.subject |
javascript:void(0); |
dc.title |
The glaucoma intensive treatment study : interim results from an ongoing longitudinal randomized clinical trial |
dc.type |
/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version |
Peer reviewed |
dc.identifier.doi |
10.1111/aos.14978 |
dc.relation.url |
http://www.scopus.com/inward/record.url?scp=85111523268&partnerID=8YFLogxK |
dc.contributor.department |
Faculty of Medicine |