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Browsing IRIS by Department "Faculty of Physical Sciences"

Browsing IRIS by Department "Faculty of Physical Sciences"

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    Application of ChatGPT for automated problem reframing across academic domains 
    Einarsson, Hafsteinn; Lund, Sigrún Helga; Jónsdóttir, Anna Helga (2024-06)
    This paper explores the potential of large language models, specifically ChatGPT, to reframe problems from probability theory and statistics, making them accessible to students across diverse academic fields including biology, economics, law, and ...
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    Association of eGFR and mortality with use of a joint model : results of a nationwide study in Iceland 
    Jónsson, Arnar Jan; Lund, Sigrún Helga; Eriksen, Bjørn O; Pálsson, Runólfur; Indriðason, Ólafur Skúli (2023-09-29)
    OBJECTIVES: Prior studies on the association of estimated glomerular filtration rate (eGFR) and mortality have failed to include methods to account for repeated eGFR determinations. The aim of this study was to estimate the association between eGFR and ...
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    Asymmetric Synthesis of Methoxylated Ether Lipids : Total Synthesis of Polyunsaturated C18:3 Omega-3 and Omega-6 MEL Triene Derivatives 
    Sigurjónsson, Svanur; Haraldsson, Gudmundur G. (2024-01)
    The asymmetric synthesis of polyunsaturated triene C18:3 n-3 and C18:3 n-6 methoxylated ether lipids (MEL) of the 1-O-alkyl-sn-glycerol type is described as possible structural candidates for a triene C18:3 MEL of an unknown identity found in a mixture ...
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    Can ultrasound on admission in active labor predict labor duration and a spontaneous delivery? 
    Hjartardóttir, Hulda; Lund, Sigrún Helga; Benediktsdóttir, Sigurlaug; Geirsson, Reynir T; Eggebø, Torbjørn M. (2021-04-23)
    Background: Identifying predictive factors for a normal outcome at admission in the labor ward would be of value for planning labor care, timing interventions, and preventing labor dystocia. Clinical assessments of fetal head station and position at ...
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    Cerebrospinal Fluid C18 Ceramide Associates with Markers of Alzheimer's Disease and Inflammation at the Pre- And Early Stages of Dementia 
    Teitsdóttir, Unnur Diljá; Halldórsson, Skarphéðinn; Rolfsson, Óttar; Lund, Sigrún H.; Jónsdóttir, María Kristín; Snædal, Jón G.; Petersen, Pétur Henry (2021-05-04)
    BACKGROUND: Understanding how dysregulation in lipid metabolism relates to the severity of Alzheimer's disease (AD) pathology might be critical in developing effective treatments. OBJECTIVE: To identify lipid species in cerebrospinal fluid (CSF) ...
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    Cholesterol not particle concentration mediates the atherogenic risk conferred by apolipoprotein B particles : a Mendelian randomization analysis 
    DBDS Genomic Consortium (2022-12-21)
    BACKGROUND AND AIMS: The causal contribution of apolipoprotein B (apoB) particles to coronary artery disease (CAD) is established. We examined whether this atherogenic contribution is better reflected by non-high-density lipoprotein cholesterol (non-HDL-C) ...
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    Cold optical design for the Large Aperture Simons Observatory telescope 
    Dicker, S. R.; Gallardo, P. A.; Gudmundsson, J. E; Mauskopf, P. D.; Ali, A.; Ashton, P. C.; Coppi, G.; Devlin, M. J.; Galitzki, N.; Ho, S. P.; Hill, C. A.; Hubmayr, J.; Keating, B.; Lee, A. T.; Limon, M.; Matsuda, F.; McMahon, J.; Niemack, M. D.; Orlowski-Scherer, J. L.; Piccirillo, L.; Salatino, M.; Simon, S. M.; Staggs, S. T.; Thornton, R.; Ullom, J. N.; Vavagiakis, E. M.; Wollack, E. J.; Xu, Z.; Zhu, N. (2018-08-15)
    The Simons Observatory will consist of a single large (6 m diameter) telescope and a number of smaller (0.5 m diameter) refracting telescopes designed to measure the polarization of the Cosmic Microwave Background to unprecedented accuracy. The large ...
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    Comparison of medication adherence to different oral anticoagulants : population-based cohort study 
    Ingason, Arnar Bragi; Hreinsson, Jóhann P.; Lund, Sigrún Helga; Ágústsson, Arnar Snær; Rumba, Edward; Pálsson, Daníel; Reynisson, Indriði E.; Guðmundsdóttir, Brynja R; Önundarson, Páll Torfi; Björnsson, Einar Stefán (2023-01-01)
    OBJECTIVE: Previous observational studies have yielded conflicting results on whether medication adherence differs between patients receiving warfarin and direct oral anticoagulants (DOACs). Importantly, no study has adequately accounted for warfarin ...
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    Comparison of the effectiveness and safety of direct oral anticoagulants : a nationwide propensity score–weighted study 
    Ingason, Arnar Bragi; Hreinsson, Johann Pall; Agustsson, Arnar Snaer; Lund, Sigrun Helga; Rumba, Edward; Palsson, Daniel Alexander; Reynisson, Indridi Einar; Guðmundsdóttir, Brynja R; Önundarson, Páll Torfi; Björnsson, Einar Stefán (2022-12-23)
    In the pivotal randomized controlled trials (RCTs) for patients with atrial fibrillation, direct oral anticoagulants (DOACs) had similar or even superior efficacy and safety compared with warfarin. However, RCTs comparing different DOACs are nonexistent ...
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    The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland : A Large-Scale Proteomics Scan in Iceland 
    Styrkarsdottir, Unnur; Lund, S.H.; Saevarsdottir, S.; Magnusson, M.I.; Gunnarsdottir, K.; Norddahl, Gudmundur L.; Frigge, Michael L.; Ivarsdottir, E.V.; Bjornsdottir, Gyda; Holm, Hilma; Thorgeirsson, Guðmundur; Rafnar, T.; Jonsdottir, I.; Ingvarsson, T.; Jonsson, H.; Sulem, P.; Thorsteinsdottir, U.; Gudbjartsson, Daniel Fannar; Stefansson, K.; Thorgeirsson, Gudmundur; Ingvarsson, Þorvaldur (2021-11)
    Objective: Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement. Methods: Using ...
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    Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations 
    arcOGEN consortium; HUNT All-In Pain; ARGO Consortium; Regeneron Genetics Center; Babis, George C; Cheung, Jason Pui Yin; Kang, Jae Hee; Kraft, Peter; Lietman, Steven A; Samartzis, Dino; Slagboom, P Eline; Stefansson, Kari; Thorsteinsdottir, Unnur; Tobias, Jonathan H; Uitterlinden, André G; Winsvold, Bendik; Zwart, John-Anker; Davey Smith, George; Sham, Pak Chung; Thorleifsson, Gudmar; Gaunt, Tom R; Morris, Andrew P; Valdes, Ana M; Tsezou, Aspasia; Cheah, Kathryn S E; Ikegawa, Shiro; Hveem, Kristian; Esko, Tõnu; Wilkinson, J Mark; Meulenbelt, Ingrid; Lee, Ming Ta Michael; van Meurs, Joyce B J; Styrkársdóttir, Unnur; Zeggini, Eleftheria (2021-09-01)
    Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 ...
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    Docosahexaenoic acid in regio- and enantiopure triacylglycerols : Oxidative stability and influence of chiral antioxidant 
    Damerau, Annelie; Ahonen, Eija; Kortesniemi, Maaria; Gudmundsson, Haraldur G.; Yang, Baoru; Haraldsson, Gudmundur G.; Linderborg, Kaisa M. (2023-02-01)
    Docosahexaenoic acid (DHA) is essential for health but easily oxidized. Yet the influence of DHA's exact location (sn-1, sn-2, or sn-3) in triacylglycerols on oxidative stability is currently unknown. This is the first study comparing oxidative stability ...
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    Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor 
    Dowsett, Joseph; Ferkingstad, Egil; Rasmussen, Line Jee Hartmann; Thørner, Lise Wegner; Magnússon, Magnús Karl; Sugden, Karen; Þorleifsson, Guðmar; Frigge, Mike; Burgdorf, Kristoffer Sølvsten; Ostrowski, Sisse Rye; Sørensen, Erik; Erikstrup, Christian; Pedersen, Ole Birger; Hansen, Thomas Folkmann; Banasik, Karina; Brunak, Søren; Tragante, Vinicius; Lund, Sigrún Helga; Stefánsdóttir, Lilja; Gunnarson, Bjarni; Poulton, Richie; Arseneault, Louise; Caspi, Avshalom; Moffitt, Terrie E.; Gudbjartsson, Daníel Fannar; Eugen-Olsen, Jesper; Stefánsson, Hreinn; Stefánsson, Kári; Ullum, Henrik (2021-06-02)
    Soluble urokinase-type plasminogen activator receptor (suPAR) is a chronic inflammation marker associated with the development of a range of diseases, including cancer and cardiovascular disease. The genetics of suPAR remain unexplored but may shed ...
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    Enteric permeability, systemic inflammation and post-discharge growth among a cohort of hospitalized children in Kenya and Pakistan. 
    Tickell, KD; Denno, DM; Saleem, A; Ali, A; Kazi, Z; Singa, BO; Otieno, C; Mutinda, C; Ochuodho, V; Richardson, BA; Ásbjörnsdóttir, KH; Hawes, SE; Berkley, JA; Walson, JL (2022-09-20)
    Objectives: To determine whether gut permeability is associated with post-discharge growth and systemic inflammation among hospitalized children in low- and middle-income countries. Methods: Children aged 2-23 months being discharged from Civil Hospital ...
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    Erratum : Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations (Cell (2021) 184(18) (4784–4818.e17), (S0092867421009417), (10.1016/j.cell.2021.07.038)) 
    HUNT All-In Pain; ARGO Consortium; Regeneron Genetics Center; arcOGEN consortium (2021-11-24)
    (Cell 184, 4784–4818.e1–e16, September 2, 2021) In this article, we carried out a multi-cohort GWAS meta-analysis for 11 osteoarthritis phenotypes. Since publication, we have become aware of the following typographical errors that were introduced during ...
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    A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis 
    DBDS Genomic Consortium; Thorsteinsdottir, Unnur (2021-02-03)
    Iron is essential for many biological functions and iron deficiency and overload have major health implications. We performed a meta-analysis of three genome-wide association studies from Iceland, the UK and Denmark of blood levels of ferritin (N = ...
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    The genomics of heart failure : design and rationale of the HERMES consortium 
    Regeneron Genetics Center (2021-12)
    Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including ...
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    Graphs, permutations and topological groups 
    Möller, Rögnvaldur (2010)
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    Histopathology and levels of proteins in plasma associate with survival after colorectal cancer diagnosis 
    Magnússon, Magnús Ingvi; Agnarsson, Bjarni Agnar; Jónasson, Jón Gunnlaugur; Tryggvason, Þórður; Aeffner, Famke; le Roux, Louise; Magnusdottir, Droplaug N.; Gunnarsdóttir, Helga Sigrún; Alexíusdóttir, Kristín K.; Gunnarsdottir, Kristbjorg; Söebech, Emilia; Runarsdottir, Hjaltey; Jónsdóttir, Erna María; Kristinsdóttir, Bjarney Sif; Olafsson, Sigurgeir; Knutsdottir, Hildur; Þorsteinsdóttir, Unnur; Úlfarsson, Magnús Örn; Guðbjartsson, Daníel Fannar; Saemundsdottir, Jona; Magnusson, Olafur T.; Norddahl, Gudmundur L.; Watson, J. E.Vivienne; Rafnar, Thorunn; Lund, Sigrún Helga; Stefánsson, Kári (2023-10-19)
    Background: The TNM system is used to assess prognosis after colorectal cancer (CRC) diagnosis. Other prognostic factors reported include histopathological assessments of the tumour, tumour mutations and proteins in the blood. As some of these factors ...
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    Incidence of and risk factors of chronic kidney disease: results of a nationwide study in Iceland 
    Jónsson, Arnar Jan; Lund, Sigrún Helga; Eriksen, Bjorn O.; Pálsson, Runólfur; Indriðason, Ólafur Skúli (2022-07-01)
    Background: Information on the incidence of chronic kidney disease (CKD) in the general population is scarce. This study examined the incidence and risk factors of CKD stages 1-5 in Iceland, based on multiple markers of kidney damage. Methods: All serum ...