dc.contributor |
Háskóli Íslands |
dc.contributor |
University of Iceland |
dc.contributor.author |
Otten, Julia |
dc.contributor.author |
Andersson, Jonas |
dc.contributor.author |
Ståhl, Jens |
dc.contributor.author |
Stomby, Andreas |
dc.contributor.author |
Saleh, Ahmed |
dc.contributor.author |
Waling, Maria |
dc.contributor.author |
Ryberg, Mats |
dc.contributor.author |
Hauksson, Jon |
dc.contributor.author |
Svensson, Michael |
dc.contributor.author |
Johansson, Bengt |
dc.contributor.author |
Olsson, Tommy |
dc.date.accessioned |
2020-10-13T14:31:16Z |
dc.date.available |
2020-10-13T14:31:16Z |
dc.date.issued |
2019-01-22 |
dc.identifier.citation |
Otten, J., et al. (2019). "Exercise Training Adds Cardiometabolic Benefits of a Paleolithic Diet in Type 2 Diabetes Mellitus." Journal of the American Heart Association 8(2): e010634. |
dc.identifier.issn |
2047-9980 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/2115 |
dc.description |
Publisher's version (útgefin grein) |
dc.description.abstract |
Background The accumulation of myocardial triglycerides and remodeling of the left ventricle are common features in type 2 diabetes mellitus and represent potential risk factors for the development of diastolic and systolic dysfunction. A few studies have investigated the separate effects of diet and exercise training on cardiac function, but none have investigated myocardial changes in response to a combined diet and exercise intervention. This 12-week randomized study assessed the effects of a Paleolithic diet, with and without additional supervised exercise training, on cardiac fat, structure, and function. Methods and Results Twenty-two overweight and obese subjects with type 2 diabetes mellitus were randomized to either a Paleolithic diet and standard-care exercise recommendations (PD) or to a Paleolithic diet plus supervised exercise training 3 hours per week (PD-EX). This study includes secondary end points related to cardiac structure and function, ie, myocardial triglycerides levels, cardiac morphology, and strain were measured using cardiovascular magnetic resonance, including proton spectroscopy, at baseline and after 12 weeks. Both groups showed major favorable metabolic changes. The PD-EX group showed significant decreases in myocardial triglycerides levels (−45%, P=0.038) and left ventricle mass to end-diastolic volume ratio (−13%, P=0.008) while the left ventricle end-diastolic volume and stroke volume increased significantly (+14%, P=0.004 and +17%, P=0.008, respectively). These variables were unchanged in the PD group. Conclusions Exercise training plus a Paleolithic diet reduced myocardial triglycerides levels and improved left ventricle remodeling in overweight/obese subjects with type 2 diabetes mellitus. |
dc.description.sponsorship |
This work was supported by grants from the Swedish Heart and Lung Foundation (20120450); King Gustav V and Queen Victoria's Foundation; The Swedish Diabetes Research Foundation (2014‐096); the County Council of Västerbotten (VLL‐460481); and Umeå University, Sweden. |
dc.format.extent |
e010634 |
dc.language.iso |
en |
dc.publisher |
Ovid Technologies (Wolters Kluwer Health) |
dc.relation.ispartofseries |
Journal of the American Heart Association;8(2) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Cardiovascular magnetic resonance imaging |
dc.subject |
Diet |
dc.subject |
Exercise |
dc.subject |
Myocardial metabolism |
dc.subject |
Type 2 diabetes mellitus |
dc.subject |
Blóðrásarsjúkdómar |
dc.subject |
Segulómun |
dc.subject |
Sykursýki |
dc.subject |
Hreyfing (heilsurækt) |
dc.title |
Exercise Training Adds Cardiometabolic Benefits of a Paleolithic Diet in Type 2 Diabetes Mellitus |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
dc.description.version |
Peer Reviewed |
dc.identifier.journal |
Journal of the American Heart Association |
dc.identifier.doi |
10.1161/JAHA.118.010634 |
dc.relation.url |
https://www.ahajournals.org/doi/10.1161/JAHA.118.010634 |
dc.contributor.department |
Læknadeild (HÍ) |
dc.contributor.department |
Faculty of Medicine (UI) |
dc.contributor.school |
Heilbrigðisvísindasvið (HÍ) |
dc.contributor.school |
School of Health Sciences (UI) |